Bone cells are responsible for sensing and converting the mechanical signals into cellular signals to drive bone adaptation and damage repair . Cell-mediated repair of bone is reported to be in preferential association with regions filled with microdamage . Although different theories have been proposed for mechanisms involved in those processes (such as substrate deformation, fluid flow shear, and hydrostatic pressure in mechanotransduction , or microcrack and osteocyte apoptosis in damage detection ), knowledge on the exact form of physical stimuli which trigger bone cells, especially in critically loaded regions of bone, is still elusive.
- Bioengineering Division
Mechanically Induced Calcium Release From Bone Matrix Triggers Intracellular Ca2+ Signalling in Osteoblasts: A Novel Mechanotransduction Mechanism
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Sun, X, Kishore, V, Fites, K, & Akkus, O. "Mechanically Induced Calcium Release From Bone Matrix Triggers Intracellular Ca2+ Signalling in Osteoblasts: A Novel Mechanotransduction Mechanism." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 333-334. ASME. https://doi.org/10.1115/SBC2011-53446
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