Heart valve development is directed by a complex interaction of molecular and mechanical cues. Both molecular and mechanical based approaches are needed to clarify these relationships. Many technologies exist for the former, but the short length scale and super-compliant material properties of embryonic valve tissue make conventional mechanical testing techniques ineffective. The pipette aspiration technique has been a useful tool in cell mechanics and has recently been applied to adult valve leaflets. Geometric effects of thin, planar tissues however compromise the utility of aspiration based measurements. Herein, we utilize pipette aspiration and a novel uni-axial micro-tensile testing apparatus to quantify the biomechanical evolution of avian embryonic heart valves. We then relate biomechanical stiffening to changes in underlying structural composition.
- Bioengineering Division
Biomechanical Analysis of Embryonic Atrioventricular Valvulogenesis
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Buskohl, PR, Gould, RA, & Butcher, JT. "Biomechanical Analysis of Embryonic Atrioventricular Valvulogenesis." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 241-242. ASME. https://doi.org/10.1115/SBC2011-53791
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