Osteoarthritis (OA) is a prevalent disease, afflicting 27 million people in the United States alone . OA is commonly thought of as “wear and tear” of the joints caused by repeated compression and shear strains. The mechanical contribution to the onset and progression of OA is unknown; however, it is likely a result of an imbalance of cartilage homeostasis, represented by a shift in biochemical and mechanical factors that typically maintain healthy joints . Cartilage homeostasis results in part from cellular mechanotransduction events, i.e. the conversion of mechanical stimuli into a biochemical response.
- Bioengineering Division
Local Shear Deformation in Whole Cartilage Explants Determined by Texture Correlation
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Henderson, JT, Shannon, G, Yuen, K, & Neu, CP. "Local Shear Deformation in Whole Cartilage Explants Determined by Texture Correlation." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 211-212. ASME. https://doi.org/10.1115/SBC2011-53496
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