Left heart side (left ventricle and left atrium) is responsible for delivering the oxygenated blood to all body organs, where a relatively strong left ventricle contraction is needed to deliver around 5 liters of blood per minute. As a consequence, the left heart side experiences a high pressure (∼150 mmHg). Therefore, the dysfunction (stenosis or incompetence) in the aortic and/or mitral heart valves in the left side of the heart is more common than the dysfunction in the pulmonary and tricuspid heart valves in the right side of the heart (Yoganathan et al., 2004). Heart valve surgical replacement is the most effective solution in severe functional heart valve disease (Pibarot and Dumesnil, 2009). Almost, half of the total implants of prosthetic heart valves (∼300,000) are mechanical (mainly bileaflet). In case of mechanical heart valve (MHV), a lifelong anti-coagulant should be taken to avoid thromboembolic events. Despite the significant improvement in valve design resulting in minimizing prosthetic valve complications (thromboembolic events or pannus formation), these complications are still possible with MHV Implantation.

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