Mechanical circulatory support (MCS) devices such as the ventricular assist devices (VADs) provide life saving short-term bridge-to-transplant solutions (1) to a large proportion of patients who suffer from chronic heart failure. Although hemodynamically efficient, such devices are burdened with high incidence of thromboembolic events due to non-physiological flow past constricted geometries where platelets (the principal cellular clotting elements in blood) are exposed to elevated shear stresses and exposure times (2) — requiring mandatory anticoagulation. We recently developed an optimization methodology — Device Thrombogenicity Emulator (DTE)(3) — that integrates device specific hemodynamic stresses (from numerical simulations) with experimental measurements of platelet activation. The DTE was successfully applied by our group to measure / optimize the thromboresistance of mechanical heart valves (MHV) (3, 4).
- Bioengineering Division
Design Optimization of Rotary Blood Pumps: Alternatives to Anticoagulation Therapy
- Views Icon Views
- Share Icon Share
- Search Site
Girdhar, G, Xenos, M, Chiu, W, Alemu, Y, Lynch, B, Jesty, J, Slepian, M, Einav, S, & Bluestein, D. "Design Optimization of Rotary Blood Pumps: Alternatives to Anticoagulation Therapy." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 173-174. ASME. https://doi.org/10.1115/SBC2011-53171
Download citation file: