The whole cadaveric rat heart can be perfused with a detergent to completely decellurize the tissue . What remains is a three-dimensional scaffold that can be repopulated with neonatal cardiac cells or rat aortic endothelial cells. However, in the development of a biological substitute to replace a tissue or organ, a critical question is how to evaluate the proposed substitute.
- Bioengineering Division
Regional Mechanical Anisotropy in Decellurized Rat Heart Ventricle
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Witzenburg, C, Raghupathy, R, Kren, SM, Taylor, DA, & Barocas, VH. "Regional Mechanical Anisotropy in Decellurized Rat Heart Ventricle." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 153-154. ASME. https://doi.org/10.1115/SBC2011-53620
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