Long-term cryopreservation of functional engineered tissues (ETs) is a key enabling technology for tissue engineering and regenerative medicine. However, a limited understanding of tissue-level biophysical phenomena during freeze/thaw (F/T) and their effects on cells and ECM microstructure poses significant challenges for i) preserving tissue functionality, and ii) controlling highly tissue-type dependent cryopreservation outcomes.
Volume Subject Area:
Biotransport in Tissue and Cellular Engineering
Topics:
Biological tissues,
Fluids,
Freezing,
Cryonics,
Biomedicine,
Performance,
Tissue engineering
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