Cerebral aneurysms tend to develop at bifurcation apices or the outer side of curved vessels where the blood vessel wall experiences complex hemodynamics. In vivo studies have recently revealed that the initiation of cerebral aneurysms is confined to a well-defined hemodynamic microenvironment. Specifically aneurysms form where the vessel wall experiences high fluid shear stress (wall shear stress, WSS) and flow is accelerating, so that the wall is exposed to a positive spatial gradient in the fluid shear stress (wall shear stress gradient, WSSG)[1,2]. Closer examination of such in vivo studies reveals that exposure of the vessel wall to equally high WSS in the presence of decelerating flow, that is, negative WSSG, does not result in aneurysm-like remodeling.
- Bioengineering Division
Differential Responses of Endothelial Cells to Positive and Negative Wall Shear Stress Gradients
- Views Icon Views
- Share Icon Share
- Search Site
Dolan, J, Singh, S, Meng, H, & Kolega, J. "Differential Responses of Endothelial Cells to Positive and Negative Wall Shear Stress Gradients." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 987-988. ASME. https://doi.org/10.1115/SBC2010-19535
Download citation file: