There are several mechanisms which may cause airway closure in the lung. In this paper, we focus on airway closure due to the capillary instability [1]. In Gauglitz and Radke’s study [2], they showed that once the ratio of film thickness to tube radius is larger than 0.12, airway closure could occur. The induced interfacial deformation creates a driving pressure which forces more liquid into a growing bulge. The interface will then deform rapidly towards the end of the closure process due to the presence of large curvatures, which create strong driving pressures and will eventually lead to the formation of a liquid plug. Due to the velocity and pressure gradients in the liquid film caused by the instability, stresses, including normal and shear stresses on the airway wall, will be induced. The epithelial cells on the inner wall of the airway may be injured by these induced stresses. The purpose of this study is to measure the stresses on airway numerically and determine if the magnitude of the stresses are sufficient to injure the epithelial cells.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Two Layer Fluid Stress Analysis During Airway Closure
Cheng-feng Tai,
Cheng-feng Tai
University of Michigan, Ann Arbor, MI
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David Halpern,
David Halpern
University of Alabama, Tuscaloosa, AL
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James B. Grotberg
James B. Grotberg
University of Michigan, Ann Arbor, MI
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Cheng-feng Tai
University of Michigan, Ann Arbor, MI
David Halpern
University of Alabama, Tuscaloosa, AL
James B. Grotberg
University of Michigan, Ann Arbor, MI
Paper No:
SBC2010-19375, pp. 649-650; 2 pages
Published Online:
July 15, 2013
Citation
Tai, C, Halpern, D, & Grotberg, JB. "Two Layer Fluid Stress Analysis During Airway Closure." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 649-650. ASME. https://doi.org/10.1115/SBC2010-19375
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