Many researchers have utilized hydrogels as substrates for cell attachment. The stiffness of these substrates has been found to influence the cellular behavior such as morphology, proliferation, growth and differentiation. Lo et al. deformed polyacrylamide substrates with a blunted microneedle and observed the movement of NIH 3T3 fibroblasts. In both pulling and pushing, the cells reversed their direction and moved away from the needle. This shows that cellular behavior is also affected by stretching the underlying substrates. In a previous study, Lin et al. have demonstrated the ability to contract DNA-crosslinked polyacrylamide hydrogels (‘DNA gels’ in short) by addition of crosslinks. Jiang et al. have utilized these DNA gels as substrates to observe the cellular responses of L929 and GFP fibroblasts to both static and dynamic substrate compliances.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Alteration of Fibroblast Cell Behavior due to Contraction of Substrate
Uday Chippada,
Uday Chippada
Rutgers, The State University of New Jersey, Piscataway, NJ
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Xue Jiang,
Xue Jiang
Rutgers, The State University of New Jersey, Piscataway, NJ
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Michelle Previtera,
Michelle Previtera
Rutgers, The State University of New Jersey, Piscataway, NJ
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Rene Schloss,
Rene Schloss
Rutgers, The State University of New Jersey, Piscataway, NJ
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Bernard Yurke,
Bernard Yurke
Boise State University, Boise, ID
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Bonnie L. Firestein,
Bonnie L. Firestein
Rutgers, The State University of New Jersey, Piscataway, NJ
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Noshir A. Langrana
Noshir A. Langrana
Rutgers, The State University of New Jersey, Piscataway, NJ
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Uday Chippada
Rutgers, The State University of New Jersey, Piscataway, NJ
Xue Jiang
Rutgers, The State University of New Jersey, Piscataway, NJ
Michelle Previtera
Rutgers, The State University of New Jersey, Piscataway, NJ
Rene Schloss
Rutgers, The State University of New Jersey, Piscataway, NJ
Bernard Yurke
Boise State University, Boise, ID
Bonnie L. Firestein
Rutgers, The State University of New Jersey, Piscataway, NJ
Noshir A. Langrana
Rutgers, The State University of New Jersey, Piscataway, NJ
Paper No:
SBC2010-19507, pp. 195-196; 2 pages
Published Online:
July 15, 2013
Citation
Chippada, U, Jiang, X, Previtera, M, Schloss, R, Yurke, B, Firestein, BL, & Langrana, NA. "Alteration of Fibroblast Cell Behavior due to Contraction of Substrate." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 195-196. ASME. https://doi.org/10.1115/SBC2010-19507
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