Within the vasculature endothelial cells are constantly exposed to dynamic mechanical forces generated by pulsatile blood flow. Two stimuli known to modulate endothelial function are shear stress and cyclic circumferential strain. Yet, in most studies these two stimuli are simultaneously coupled in-vivo, making it very difficult to understand their individual contributions to vascular disease. Some attempts have been made to de-couple stretch and shear stress in-vitro by using different cell lines in a variety of stretch systems and flow chambers, straying from reality and making it hard to draw definitive conclusions. In this study we wish to find a compromise between the in-vivo and in-vitro work of the past by studying the independent effects of shear stress and cyclic stretch and how they contribute to endothelial dysfunction.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Autonomous Effects of Shear Stress and Cyclic Circumferential Stretch Regarding Endothelial Dysfunction and Oxidative Stress: An Ex Vivo Arterial Model
Tyler Thacher,
Tyler Thacher
Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
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Rafaela da Silva,
Rafaela da Silva
Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
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Paolo Silacci,
Paolo Silacci
Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
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Nikos Stergiopulos
Nikos Stergiopulos
Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
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Tyler Thacher
Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
Rafaela da Silva
Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
Paolo Silacci
Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
Nikos Stergiopulos
Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
Paper No:
SBC2009-205503, pp. 993-994; 2 pages
Published Online:
July 19, 2013
Citation
Thacher, T, da Silva, R, Silacci, P, & Stergiopulos, N. "Autonomous Effects of Shear Stress and Cyclic Circumferential Stretch Regarding Endothelial Dysfunction and Oxidative Stress: An Ex Vivo Arterial Model." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 993-994. ASME. https://doi.org/10.1115/SBC2009-205503
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