Cancer is the leading cause of death in Japan as well as many other countries. One of the most serious problem of cancer is that cancer cells often migrate to a distant part of the body, referred to as metastasis. The rheological properties of cancer cells have been investigated by some reserchers [1,2]. However, the correlations between the metastasis and the rheological properties are still unclear, because of limited number of experimental cases reported so far. In this study, we used two kinds of human breast cancer cell lines, MCF-7 and KPL-4. It is known that KPL-4 has much higher metastatic property than MCF-7. The rheological properties of these cells were measured by a micropipette aspiration method [3,4]. By comparing Young’s modulus between two kinds of cancer cells, we discuss the correlations between the metastasis and the cell deformability.
- Bioengineering Division
Rheology of Cancer Cells With Different Metastatic Properties
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Yoshimoto, T, Ishikawa, T, Matsuki, N, Fujiwara, H, Imai, Y, Ueno, H, Takeda, M, & Yamaguchi, T. "Rheology of Cancer Cells With Different Metastatic Properties." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 765-766. ASME. https://doi.org/10.1115/SBC2009-206593
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