While the pathogenesis of an intracranial aneurysm (IA) is poorly understood, it has been generally postulated to be related to hemodynamic insult. IAs are predominantly located at apices of arterial bifurcations or outer curves on or near the Circle of Willis, suggesting a potential role of the specific hemodynamics at such locations characterized by high wall shear stress (WSS). Clinically, new IA formation has been observed following local flow increase.
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High Wall Shear Stress and Positive Wall Shear Stress Gradient Trigger the Initiation of Intracranial Aneurysms
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Metaxa, E, Tremmel, M, Xiang, J, Kolega, J, Mandelbaum, M, Siddiqui, A, Mocco, J, & Meng, H. "High Wall Shear Stress and Positive Wall Shear Stress Gradient Trigger the Initiation of Intracranial Aneurysms." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 523-524. ASME. https://doi.org/10.1115/SBC2009-206395
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