There has been a clear need for better understanding of the progression of abdominal aortic aneurysm (AAA) and obtaining reliable prediction of the AAA rupture. Finite element analysis (FEA) using non-axisymmetric models of AAAs provides better estimation of stress distribution in the aneurysmal wall with complex shapes . However, FEA alone does not provide a mathematical description for the evolution of an AAA through growth and remodeling (G&R). A computational framework for modeling stress-mediated growth and structural remodeling of the arterial wall under physiological and pathological conditions has been suggested using a constrained mixture assumption . Stress-mediated enlargement of intracranial aneurysms has been investigated using idealized axisymmetric geometries [3,4]. The kinetics of stress-mediated turnover of collagen fiber families and degradation of elastin were found to have particular importance in the G&R of aneurysmal wall.
- Bioengineering Division
Towards Patient-Specific Modeling of an Enlarging Abdominal Aortic Aneurysm
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Zeinali-Davarani, S, Sheidaei, A, & Baek, S. "Towards Patient-Specific Modeling of an Enlarging Abdominal Aortic Aneurysm." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 509-510. ASME. https://doi.org/10.1115/SBC2009-205488
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