Extravasation of large therapeutic agents into tumor tissue following systemic injection is marked by heterogeneous distribution. Factors that contribute to this phenomenon include high interstitial fluid pressure (IFP) and non-uniform vascular permeability; they have been shown to be major obstacles delivery of macromolecules clinically [1]. Until recently, blood flow in a single vessel or capillary networks with variations in space and time has been explored using computational tumor models [2]. These studies do not account for heterogeneous tissue transport properties in regions of leakier vessels [3].

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