Extravasation of large therapeutic agents into tumor tissue following systemic injection is marked by heterogeneous distribution. Factors that contribute to this phenomenon include high interstitial fluid pressure (IFP) and non-uniform vascular permeability; they have been shown to be major obstacles delivery of macromolecules clinically . Until recently, blood flow in a single vessel or capillary networks with variations in space and time has been explored using computational tumor models . These studies do not account for heterogeneous tissue transport properties in regions of leakier vessels .
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A Computational Model of Interstitial Transport in Murine Sarcoma With Heterogeneous Vasculature: A Sensitivity Analysis
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Pishko, GL, Astary, GW, Mareci, TH, & Sarntinoranont, M. "A Computational Model of Interstitial Transport in Murine Sarcoma With Heterogeneous Vasculature: A Sensitivity Analysis." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1135-1136. ASME. https://doi.org/10.1115/SBC2009-206746
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