Early stage cerebral aneurysms are characterized by the disruption of the internal elastic lamina (IEL). The cause of this breakdown is still not understood, but it has been conjectured to be caused by fatigue failure or alternatively by a breakdown in homeostatic mechanisms in the wall arising from some aspect of the local hemodynamics, e.g. .
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A Structural Multi-Mechanism Damage Model for Cerebral Arterial Tissue and its Finite Element Implementation
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Li, D, & Robertson, AM. "A Structural Multi-Mechanism Damage Model for Cerebral Arterial Tissue and its Finite Element Implementation." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 965-966. ASME. https://doi.org/10.1115/SBC2008-193112
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