Non-uniform extravasation from blood vessels, elevated interstitial fluid pressure (IFP), and transport by bulk fluid motion in the extracellular space have all been determined to contribute to the non-uniform tissue distribution of systemically delivered agents in solid tumors. The aforementioned factors can lead to inadequate and uneven uptake in tumor tissue which has been shown to be a major obstacle to macromolecules in clinical cancer therapy . Recently developed computational tumor models have described blood flow either in a single vessel or capillary network with variations in space and time . These studies do not account for heterogeneous tissue transport properties in regions of leakier vessels .
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High Resolution DCE-MRI Vascular Characterization of Murine Sarcoma and Human Renal Cell Carcinoma for Computational Modeling
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Pishko, GL, Astary, GW, Mareci, TH, & Sarntinoranont, M. "High Resolution DCE-MRI Vascular Characterization of Murine Sarcoma and Human Renal Cell Carcinoma for Computational Modeling." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 809-810. ASME. https://doi.org/10.1115/SBC2008-193179
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