As the baby boomer generation ages, knee osteoarthritis (OA) will become increasingly prevalent in our society. Articular cartilage damage in the knee is highly dependent upon subject-specific kinematics and load distribution inside the joint. In particular, researchers have hypothesized that overloading of the medial compartment is a primary contributing factor to the development of the disease . However, since medial compartment load cannot be measured non-invasively in vivo, researchers typically use the external knee adduction moment during stance phase as a surrogate measure. This quantity has been correlated with the medial tibial contact force measured from an instrumented knee implant  and with the risk of disease progression over time .
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Prediction of Internal Contact Forces at the Knee From External Measurements
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Walter, JP, Banks, SA, D’Lima, DD, & Fregly, BJ. "Prediction of Internal Contact Forces at the Knee From External Measurements." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 685-686. ASME. https://doi.org/10.1115/SBC2008-193169
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