Cellular mechanics involves the ability of cells to sense and respond to external forces. The type of deformations that cells undergo such as stretching, compression or shearing depends on physiological conditions such as how muscle deforms during movement. Using a custom fabricated stretching device, we focused on investigating how statically applied mechanical stretch affects syndecan-4, focal adhesion complexes and phosphorylated focal adhesion kinase (p-FAK). These results have potential implications in a variety of fields including biophysics, mechanotransduction, and cellular structure.
- Bioengineering Division
Effects of Mechanical Strain on Syndecan-4, Focal Adhesion Complexes, and Site-Specific FAK Phosphorylation
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Cheng, C, Steward, RL, Jr., Wang, DL, & LeDuc, PR. "Effects of Mechanical Strain on Syndecan-4, Focal Adhesion Complexes, and Site-Specific FAK Phosphorylation." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 265-266. ASME. https://doi.org/10.1115/SBC2008-192360
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