Mitral valve (MV) disease affects millions worldwide. An important goal of present-day heart valve research is to create bioengineered tissue valves to replace diseased mitral valves, if it is judged that mitral repair will not be durable. The design of such valves will pivot on understanding the stresses acting in the native MV leaflets to design a bioprosthesis which will withstand these stresses. In order to quantify such stresses in vivo, we utilized radiopaque marker technology and performed an “inverse” finite element analysis of the resulting 4-D data to determine the material properties of the anterior MV leaflet in the beating ovine heart. We then used these material properties in a “forward” finite element analysis to estimate the stresses in the native anterior MV leaflet.
- Bioengineering Division
In Vivo Stresses in the Ovine Anterior Mitral Valve Leaflet
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Krishnamurthy, G, Itoh, A, Bothe, W, Ennis, DB, Swanson, JC, Kuhl, E, Miller, DC, & Ingels, NB. "Quantification of In Vivo Stresses in the Ovine Anterior Mitral Valve Leaflet." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 131-132. ASME. https://doi.org/10.1115/SBC2008-192295
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