A highly resolved 3D geometry of a bileflet mechanical heart valve (MHV) was constructed to study the contribution of the forward and regurgitant flow phases to platelet damage. Platelet stress accumulation during repetitive passages past the valve was calculated using a damage accumulation model in pertinent trajectories. Additionally a discrete particles dynamics (DPD) multiscale modeling approach, which widely departs from the traditional continuum approach, was applied to this MHV geometry. It generated viscous blood flow velocity distributions, and is envisioned to further facilitate multiscale simulations of flow induced thrombogenicity in blood recirculating devices.

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