Electroporation is the phenomenon in which permeability of the cell membrane to ions and macromolecules is increased by exposing the cell to short (microsecond to millisecond) high voltage electric pulses . The application of the electric pulse can have no effect, can have a transient effect known as reversible electroporation, or can cause permanent permeation known as irreversible electroporation (IRE) which leads to non-thermal cell death by necrosis [1, 2].
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Irreversible Electroporation (IRE) to Treat Brain Tumors
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Garcia, PA, Robertson, J, Rossmeisl, J, & Davalos, RV. "Irreversible Electroporation (IRE) to Treat Brain Tumors." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 101-102. ASME. https://doi.org/10.1115/SBC2008-192992
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