Interaction of spherical particles with cells and within animals has been studied extensively, but the effects of shape have received little attention. Here we use highly stable, polymer micelle assemblies known as ‘filomicelles’ to compare the transport and trafficking of these flexible filaments to spheres of similar chemistry. In rodents, filomicelles persisted in the circulation up to 1 week after intravenous injection. This is about ten-fold longer than their spherical counterparts and more persistent than any known synthetic nanoparticle. With cells and in fluid flow conditions, spheres and short filomicelles are taken up by cells more readily than longer filaments because the latter are extended by the flow. Preliminary results further demonstrate that filomicelles can effectively deliver the anticancer drug paclitaxel and shrink human-derived tumors in mice. These findings redefine what is ‘nano’ for circulating vehicles and perhaps also lend insight into shape advantages of natural filoviruses.
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ASME 2007 Summer Bioengineering Conference
June 20–24, 2007
Keystone, Colorado, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4798-5
PROCEEDINGS PAPER
Soft Filaments Circulate Longer Than Spherical Particles - Shape Effects in Flow and Drug Delivery
Dennis E. Discher,
Dennis E. Discher
University of Pennsylvania, Philadelphia, PA
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Paul Dalhaimer
Paul Dalhaimer
University of Pennsylvania, Philadelphia, PA
Search for other works by this author on:
Dennis E. Discher
University of Pennsylvania, Philadelphia, PA
Paul Dalhaimer
University of Pennsylvania, Philadelphia, PA
Paper No:
SBC2007-176746, pp. 125-126; 2 pages
Published Online:
March 12, 2014
Citation
Discher, DE, & Dalhaimer, P. "Soft Filaments Circulate Longer Than Spherical Particles - Shape Effects in Flow and Drug Delivery." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 125-126. ASME. https://doi.org/10.1115/SBC2007-176746
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