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Proceedings Volume Cover

ASME 2011 Summer Bioengineering Conference

June 22–25, 2011

Farmington, Pennsylvania, USA

Conference Sponsors:

ISBN:

978-0-7918-5458-7

In This Volume

Arterial Mechanics (6)
Atherosclerosis I (6)
Atherosclerosis II (6)
Bioheat Transfer and BioNanotechnology (6)
Biological Interfaces: Mechanics and Synthesis (6)
Biomechanics of Aortic Aneurysms (6)
Biomechanics of Injury I (6)
Biomechanics of Injury II (6)
BioMEMS and Microfluidics (6)
Bio-Thermal Engineering (6)
Biotransport Education (6)
Biotransport in Tissue and Cellular Engineering (6)
Cardiac Mechanics (6)
Cardiovascular Design and Devices I (6)
Cardiovascular Design and Devices II (6)
Cardiovascular Diagnostics (6)
Cardiovascular Tissue Engineering (6)
Cartilage/Disc Mechanics (6)
CFD Modeling and Applications (5)
Grand Challenge Competition to Predict In Vivo Knee Loads (4)
Heart Valve Mechanobiology (6)
Heart Valves: Leaflet and Annulus Mechanics (6)
Hemodynamics of Aneurysms (6)
Human Dynamics (6)
Material and Structural Characterization of Bone (6)
Mechanical Circulatory Support (6)
Mechanoregulation of Bone: A Tribute to Rik Huiskes (6)
Mechanotransduction and Sub-Cellular Biophysics I (6)
Mechanotransduction and Sub-Cellular Biophysics II (6)
Mechanotransduction and Sub-Cellular Biophysics III (6)
Model Systems and the Pericellular Environment (6)
Multiscale Modeling in Biotransport (6)
Musculoskeletal Design and Devices (6)
Musculoskeletal Tissue Engineering (6)
Nano, Micro and Multiscale Mechanics I (6)
Nano, Micro and Multiscale Mechanics II (6)
Ocular and Other Solid Mechanics (6)
PhD Student Paper Competition: Biomaterials and Nanotechnology (6)
PhD Student Paper Competition: Cardiovascular Flow (6)
PhD Student Paper Competition: Cell Mechanics and Signaling (6)
PhD Student Paper Competition: Microdevices and Biotransport (6)
PhD Student Paper Competition: Orthopaedic Biomechanics (6)
PhD Student Paper Competition: Physical Effects on Cells (6)
Reduced Order Models and Applications (6)
Rehabilitation, Prosthetics and Orthotics (6)
Respiratory Flows (6)
Spine I (6)
Spine II (5)
Targeted Delivery and Electroporation (6)
Tendon/Ligament Mechanics (6)
Tissue Growth and Remodeling: Computational Modeling (6)
Tissue Growth and Remodeling: Experiments (6)
Undergraduate Design Competition in Rehabilitation and Assistive Devices (6)
Upper and Lower Extremity (6)
Woo Symposium: Application of Robotics to Analyze Joint Stability (6)
Woo Symposium: Computational Modeling of Ligaments and Tendons (6)
Woo Symposium: Functional Tissue Engineering of Ligaments and Tendons (6)
Woo Symposium: Tissue Mechanics (6)
Poster Session I: Aneurysms (11)
Poster Session I: Atherosclerosis (11)
Poster Session I: BioMEMS and Microfluidics (5)
Poster Session I: Biotransport (10)
Poster Session I: Cardiovascular Design and Devices (7)
Poster Session I: Cardiovascular Tissue Mechanics (19)
Poster Session I: Design and Devices (10)
Poster Session I: Joint and Spine Mechanics (17)
Poster Session I: Morphogenesis, Micropatterning and Cellular Microenvironment (5)
Poster Session I: Musculoskeletal Tissue Engineering (9)
Poster Session I: Student Paper Competition (BS Level) Musculoskeletal Biomechanics and Imaging (9)
Poster Session I: Student Paper Competition (BS Level) Tissue Engineering, Biotransport and Cell Mechanics (11)
Poster Session I: Student Paper Competition (MS Level) Biotransport, Biofluids, Tissue and Cellular Engineering (14)
Poster Session I: Student Paper Competition (MS Level) Dynamics, Design, Rehabilitation and Injury (9)
Poster Session I: Student Paper Competition (MS Level) Solid Mechanics (16)
Poster Session I: Tissue Engineering of Interfaces (4)
Poster Session II: Biomechanics of Injury (13)
Poster Session II: Biotransport (13)
Poster Session II: Bone Mechanics (6)
Poster Session II: Cardiac and Cardiovascular Hemodynamics (7)
Poster Session II: Cardiovascular Design and Devices (9)
Poster Session II: Cardiovascular Imaging and Image Based Modeling (10)
Poster Session II: Cardiovascular Tissue Engineering (7)
Poster Session II: Cellular and Molecular Biomechanics (7)
Poster Session II: Design and Devices (8)
Poster Session II: Growth, Remodeling and Repair (11)
Poster Session II: Heart Valve (9)
Poster Session II: Human Dynamics and Rehabilitation (7)
Poster Session II: Mechanotransduction and Sub-Cellular Biophysics (5)
Poster Session II: Multiscale Mechanics (5)
Poster Session II: Musculoskeletal Soft Tissue Mechanics (18)
Poster Session II: Other Solid Mechanics (16)
Poster Session II: Respiratory and Lymphatics (8)
Poster Session II: Tissue Engineering (4)
Poster Session II: Tissue Engineering of Model Systems (4)

ASME 2011 Summer Bioengineering Conference, Parts A and B

Arterial Mechanics

Mechanics and Modeling of Postnatal Arterial Development in Wild-Type and Elastin-Insufficient Mice

Jeffrey K. Cheng, Victoria Le, Robert P. Mecham, Jessica E. Wagenseil

SBC 2011; 1-2doi:https://doi.org/10.1115/SBC2011-53140

Topics: Blood , Feedback , Hemodynamics , Mechanical properties , Modeling , Muscle , Pressure , Proteins , Reservoirs , Stress

Penetration Mechanics of Endovascular Stent Graft Barbs in Aortic Tissue

Kathleen Lin, Benjamin Berkowitz, Madhavan L. Raghavan

SBC 2011; 3-4doi:https://doi.org/10.1115/SBC2011-53357

Topics: Biological tissues , Stents , Needles , Aneurysms , Aorta , Membranes , Pins (Engineering) , Probability , Silicones , Soft tissues

Layer-Specific Distributed Collagen Fiber Orientations in Human Arteries, From Thoracic Aorta to Common Iliac

Andreas J. Schriefl, Peter Regitnig, David M. Pierce, Gerhard A. Holzapfel

SBC 2011; 5-6doi:https://doi.org/10.1115/SBC2011-53403

Topics: Aorta , Fibers , Biological tissues , Microscopy

An Investigation on the Use of Silicone to Model Arterial Tissue Behaviour in the Idealised Tuning-Fork Model of the Carotid Bifurcation

J. J. Mulvihill, M. R. O’Donnell, B. M. O’Connell, M. T. Walsh

SBC 2011; 7-8doi:https://doi.org/10.1115/SBC2011-53440

Topics: Bifurcation , Biological tissues , Silicones , Atherosclerosis , Cardiovascular system , Geometry , Mechanical behavior

Buckling Behavior of Arteries Under Torsion

Justin R. Garcia, Shawn D. Lamm, Hai-Chao Han

SBC 2011; 9-10doi:https://doi.org/10.1115/SBC2011-53652

Topics: Atherosclerosis , Blood , Blood flow , Blood vessels , Buckling , Deformation , Diabetes , Diseases , Pressure , Propellers

A New Form of Residual Deformation in the Coronary Artery: Implications for In Vivo Mechanical Behavior

Ruoya Wang, Rudolph L. Gleason, Jr.

SBC 2011; 11-12doi:https://doi.org/10.1115/SBC2011-53705

Topics: Coronary arteries , Deformation , Mechanical behavior , Stress , Diseases , Shear (Mechanics) , Shear stress , Stress concentration , Vessels

Atherosclerosis I

Degree of Retrograde Flow and Its Effect on Local Hemodynamics and Plaque Distribution in an Aortic Regurgitation Murine Model of Atherosclerosis

Yiemeng Hoi, Mark Van Doormaal, Yu-Qing Zhou, Xiaoli Zhang, R. Mark Henkelman, David A. Steinman

SBC 2011; 13-14doi:https://doi.org/10.1115/SBC2011-53161

Topics: Atherosclerosis , Flow (Dynamics) , Hemodynamics , Aorta , Ultrasonic measurement , Ultrasound , Valves

On the Use of In Vivo Measured Flow Rates as Boundary Conditions for Image-Based Hemodynamic Models of the Human Aorta

Diego Gallo, Gianluca De Santis, Federica Negri, Daniele Tresoldi, Giovanna Rizzo, Raffaele Ponzini, Diana Massai, Marco Deriu, Marcello Cadioli, Benedict Verhegghe, Patrick Segers, Alberto Redaelli, Umberto Morbiducci

SBC 2011; 15-16doi:https://doi.org/10.1115/SBC2011-53232

Topics: Aorta , Boundary-value problems , Flow (Dynamics) , Hemodynamics , Magnetic resonance imaging , Computational fluid dynamics , Engineering simulation , Simulation , Blood flow , Aortic arch

Rightward and Leftward Head Rotation Influence the Geometric Features of the Healthy Carotid Bifurcation

Nicolas Aristokleous, Ioannis Seimenis, Yannis Papaharilaou, Georgios Georgiou, Brigitta C. Brott, Andreas S. Anayiotos

SBC 2011; 17-18doi:https://doi.org/10.1115/SBC2011-53243

Topics: Bifurcation , Rotation , Geometry , Sleep , Hemodynamics , Atherosclerosis , Carotid arteries , Particulate matter , Shear stress

Database of Rabbit Aortic Geometries for Use in Computational Flow Studies

V. Peiffer, M. Rowland, P. D. Weinberg, S. J. Sherwin

SBC 2011; 19-20doi:https://doi.org/10.1115/SBC2011-53469

Topics: Databases , Flow (Dynamics) , Atherosclerosis , Blood flow , Diseases , Risk

Geometric and Hemodynamic Evaluation of 3-Dimensional Reconstruction Techniques for the Assessment of Coronary Artery Wall Shear Stress in the Setting of Clinical Disease Progression

Lucas H. Timmins, Jin Suo, Parham Eshtehardi, Saurabh S. Dhawan, Michael C. McDaniel, John N. Oshinski, Habib Samady, Don P. Giddens

SBC 2011; 21-22doi:https://doi.org/10.1115/SBC2011-53528

Topics: Coronary arteries , Diseases , Hemodynamics , Shear stress , Computer-aided design , Atherosclerosis , Biomedicine , Flow (Dynamics) , Patient treatment , Physiology

Thrombus Initiation With Subsequent Growth Measured for Physiological Shear and High Pathological Shear

David L. Bark, Jr., Andrea N. Para, David N. Ku

SBC 2011; 23-24doi:https://doi.org/10.1115/SBC2011-53865

Topics: Physiology , Shear (Mechanics) , Thrombosis , Hemodynamics , Atherosclerosis , Diseases , Flow (Dynamics) , Platelets , Rupture

Atherosclerosis II

Stress-Strain Profile of Carotid Plaque With and Without Juxtaluminal Hemorrhage/Thrombus: A Possible Mechanism for Subsequent Cerebrovascular Events

Zhongzhao Teng, Umar Sadat, Jonathan H. Gillard

SBC 2011; 25-26doi:https://doi.org/10.1115/SBC2011-53078

Topics: Atherosclerosis , Risk , Stress , Thrombosis , Transients (Dynamics)

A Predictive Method for Human Carotid Plaque Rupture Using In Vivo Serial MRI With Follow-Up Scan Showing Actual Rupture and MRI-Based 3D Models With Fluid-Structure Interactions

Zheyang Wu, Chun Yang, Dalin Tang

SBC 2011; 27-28doi:https://doi.org/10.1115/SBC2011-53098

Topics: Fluid structure interaction , Magnetic resonance imaging , Rupture , Three-dimensional models , Atherosclerosis , Biomedical imaging , Computer simulation , Risk

Risk of Rupture in Coronary Vulnerable Plaques: Fluid-Structure Interaction Studies Using Patient Based Micro-CT and IVUS Measurements

Xuan Liang, Suraj Rambhia, Michalis Xenos, Yared Alemu, Natalia Maldonado, Adreanne Kelly, Ifat Lavi, Shmuel Einav, Sheldon Weinbaum, Luis Cardoso, Danny Bluestein

SBC 2011; 29-30doi:https://doi.org/10.1115/SBC2011-53143

Topics: Fluid structure interaction , Risk , Rupture , Stress , Vessels , Anisotropy , Biological tissues , Engineering simulation , Failure , Resolution (Optics)

Human Coronary Microcalcifications: 3D High Resolution Characterization of Frequency Size and Distribution

Natalia Maldonado, Adreanne Kelly, Yuliya Vengrenyuk, John T. Fallon, Renu Virmani, Luis Cardoso, Sheldon Weinbaum

SBC 2011; 31-32doi:https://doi.org/10.1115/SBC2011-53198

Topics: Coronary arteries , Diseases , Resolution (Optics) , Rupture

Correlation Between Plaque Composition and Shear Stress Using Three-Dimensional Reconstructed Histology and Computational Fluid Dynamics of Diseased Human Carotid Arteries

Kim van der Heiden, Harald C. Groen, Lambert Speelman, Aad van der Lugt, Anton F. W. van der Steen, Wiro Niessen, Frank J. H. Gijsen, Jolanda J. Wentzel

SBC 2011; 33-34doi:https://doi.org/10.1115/SBC2011-53639

Topics: Carotid arteries , Computational fluid dynamics , Shear stress , Atherosclerosis

Three Dimensional Reconstruction of the Components of the Carotid Plaque From Standard CT Medical Images

Dipankar Biswas, Francis Loth, Susan McCormick, Hisham Bassiouny

SBC 2011; 35-36doi:https://doi.org/10.1115/SBC2011-53750

Topics: Biomedical imaging , Carotid arteries , Computer software , Computerized tomography , Graphical user interfaces

Bioheat Transfer and BioNanotechnology

Enhanced Transmucosal Transport Using Osmolyte-Mediated Fluid-Matrix Interaction

Ka Yaw Teo, Basma Ibrahim, Seungman Park, Yeo Yoon, Bumsoo Han

SBC 2011; 37-38doi:https://doi.org/10.1115/SBC2011-53102

Topics: Biological tissues , Cavities , Drug delivery systems , Fluids , Nanoparticles , Surface science

Attachment State Shifts Viability Versus Cooling Rate (Inverted U Curve) During Freezing for Human Dermal Fibroblasts

Jeunghwan Choi, John C. Bischof

SBC 2011; 39-40doi:https://doi.org/10.1115/SBC2011-53156

Topics: Cooling , Fibroblasts , Freezing , Biological tissues , Biophysics , Cryobiology , Cryonics , Performance

Temperature Field Reconstruction for the Application of Wireless Implantable Temperature Sensors in Cryosurgery

Chandrajit Thaokar, Yoed Rabin

SBC 2011; 41-42doi:https://doi.org/10.1115/SBC2011-53319

Topics: Biological tissues , Biomedical imaging , Freezing , Temperature , Temperature sensors

Hydraulic Resistance of a Novel Hollow-Core Microneedle Design

R. L. Hood, M. A. Kosoglu, C. G. Rylander

SBC 2011; 43-44doi:https://doi.org/10.1115/SBC2011-53845

Topics: Design , Microneedles , Biological tissues , Drug delivery systems , Fluids , Manufacturing , Microscale devices , Needles , Permeability , Skin

Synthesis and Cytotoxicity Analysis of Carbon Nanohorn-Quantum Dot Complexes

Kristen A. Zimmermann, Jianfei Zhang, Harry Dorn, Christopher Rylander, Marissa Nichole Rylander

SBC 2011; 45-46doi:https://doi.org/10.1115/SBC2011-53968

Topics: Carbon , Biomedicine , Carbon nanotubes , Nanoparticles , Catalysts , Drug delivery systems , Graphene , Imaging , Lasers , Metals

Enrichment of Cancer Cells Using a High Throughput Contactless Dielectrophoretic (CDEP) Microfluidic Device

Alireza Salmanzadeh, Hadi Shafiee, Mike B. Sano, Mark A. Stremler, Rafael V. Davalos

SBC 2011; 47-48doi:https://doi.org/10.1115/SBC2011-54011

Topics: Cancer , Microfluidics , Blood , Tumors , Electrical properties , Particulate matter , Biomedicine , Dielectrophoresis , Electric fields , Electrical conductivity

Biological Interfaces: Mechanics and Synthesis

A Modular System to Examine Fibroblastic Differentiation of Mesenchymal Stem Cells Under Tensile Loading in Response to Changes in the Extracellular Environment

Johnna S. Temenoff

SBC 2011; 49-50doi:https://doi.org/10.1115/SBC2011-53704

Topics: Stem cells , Tendons , Biological tissues , Bone , Hydrogels , Bioreactors , Joint mechanics , Osteoarthritis , Wounds

Hydration and Crosslinking Effects on the Elastic and Viscoelastic Properties of Collagen Scaffolds

Bin Xu, Katherine Yanhang Zhang

SBC 2011; 51-52doi:https://doi.org/10.1115/SBC2011-53737

Topics: Viscoelasticity , Biological tissues , Thin films , Blood vessels , Bone , Energy dissipation , Energy storage , Fibers , Fluids , Proteins

Material Properties of the Developing Bone-Cartilage Interface in the Human Fetal Spine

Rachel C. Paietta, Evalina Burger, Virginia L. Ferguson

SBC 2011; 53-54doi:https://doi.org/10.1115/SBC2011-53774

Topics: Bone , Cartilage , Materials properties , Biological tissues , Mechanical properties , Disks , Electron microscopy , Intervertebral discs , Nanoindentation , Soft tissues

On the Mechanics of Partially Mineralized Tissues and Their Implications for the Attachment of Tendon to Bone

Yanxin Liu, Victor Birman, Chanqing Chen, Stavros Thomopoulos, Guy M. Genin

SBC 2011; 55-56doi:https://doi.org/10.1115/SBC2011-53991

Topics: Biological tissues , Bone , Tendons , Minerals , Nanoscale phenomena

Directed Cellular Dynamics on Aligned STEP Fibrous Mechanistic Microenvironments

Kevin Sheets, Amrinder Nain

SBC 2011; 57-58doi:https://doi.org/10.1115/SBC2011-54009

Topics: Dynamics (Mechanics) , Biological tissues , Electrospinning , Glass , Manufacturing , Mechanical properties , Nanofibers , Polymer fibers , Proteins , Spin (Aerodynamics)

Collagen Scaffold-Membrane Composites for Mimicking Orthopedic Interfaces

Brendan A. C. Harley

SBC 2011; 59-60doi:https://doi.org/10.1115/SBC2011-54026

Topics: Composite materials , Membranes , Orthopedics , Tendons , Wounds , Biological tissues , Bone , Shells , Biomaterials , Biomechanics

Biomechanics of Aortic Aneurysms

Use of the Photoelastic Method to Determine the Wall Stress in Realistic Abdominal Aortic Aneurysm Models

Barry J. Doyle, Anthony Callanan, John Killion, Timothy M. McGloughlin

SBC 2011; 61-62doi:https://doi.org/10.1115/SBC2011-53268

Topics: Aneurysms , Stress , Rupture , Biomechanics , Finite element analysis , Risk , Numerical analysis , Pressure , Strain gages

A Growth and Remodeling Approach to AAA Modeling: Feasibility and Initial Insights

John S. Wilson, Seungik Baek, Jay D. Humphrey

SBC 2011; 63-64doi:https://doi.org/10.1115/SBC2011-53525

Topics: Aneurysms , Biomedical imaging , Modeling , Risk , Rupture , Surgery

Quantifying the Structural and Mechanical Changes in Elastase Degraded Arteries as an In Vitro Model of Aortic Aneurysm

Ming-Jay Chow, Jarred Raymund Mondonedo, Katherine Yanhang Zhang

SBC 2011; 65-66doi:https://doi.org/10.1115/SBC2011-53576

Topics: Aneurysms , Biological tissues , Rupture , Failure , Fibers , Maintenance , Mechanical properties , Modeling , Muscle , Stiffness

Biomechanical and Microstructural Analysis of Wildtype (C57BL6) Mouse Aorta

Darren Haskett, Greg Johnson, Mohamad Azhar, Jonathan Vande Geest

SBC 2011; 67-68doi:https://doi.org/10.1115/SBC2011-53729

Topics: Aorta , Biomechanics , Diseases , Aneurysms , Biological tissues

Association of Mechanical Properties and Collagen Content With Valve Morphology in Ascending Thoracic Aortic Aneurysmal Tissue

Joseph E. Pichamuthu, Julie A. Phillippi, Deborah A. Cleary, Douglas W. Chew, John Hempel, Thomas G. Gleason, David A. Vorp

SBC 2011; 69-70doi:https://doi.org/10.1115/SBC2011-53873

Topics: Biological tissues , Mechanical properties , Valves , Rupture , Aneurysms , Aorta , Biomechanics , Risk , Surgery

Machine Learning Techniques for the Assessment of AAA Rupture Risk

Judy Shum, Elena S. Di Martino, Satish C. Muluk, Ender A. Finol

SBC 2011; 71-72doi:https://doi.org/10.1115/SBC2011-53947

Topics: Machine learning , Risk , Rupture , Geometry , Shapes , Wall thickness , Algorithms , Aneurysms , Computerized tomography , Diseases

Biomechanics of Injury I

Closed Joint Traumatic Impaction and Its Influence on Meniscal Cell Viability

Megan L. Killian, Roger C. Haut, Tammy L. Haut Donahue

SBC 2011; 73-74doi:https://doi.org/10.1115/SBC2011-53001

Topics: Anterior cruciate ligament , Bone , Cartilage , Chondrocytes , Damage , Knee , Osteoarthritis , Patient treatment , Rupture , Wear

The Duration of a Nerve Root Compression Modulates Evoked Neuronal Responses in a Rat Model of Painful Injury

Kristen J. Nicholson, Beth A. Winkelstein

SBC 2011; 75-76doi:https://doi.org/10.1115/SBC2011-53082

Topics: Compression , Wounds , Transients (Dynamics) , Biological tissues , Heat conduction , Risk , Spinal cord

Development of a Biofidelic Material Model for Brain Tissue

Sandeep Kulathu, David L. Littlefield

SBC 2011; 77-78doi:https://doi.org/10.1115/SBC2011-53136

Topics: Biological tissues , Brain , Simulation , Anisotropy , Composite materials , Constitutive equations , Fibers , Stress , Traumatic brain injury , Viscoelastic materials

Mechanism of Injury in a High Ankle Sprain: A Simulation Study

Feng Wei, Jerrod E. Braman, Eric G. Meyer, John W. Powell, Roger C. Haut

SBC 2011; 79-80doi:https://doi.org/10.1115/SBC2011-53152

Topics: Injury mechanisms , Simulation , Rotation , Wounds

Emulating the Interfacial Kinematics of CNS White Matter With Finite Element Techniques

Yi Pan, Assimina A. Pelegri, David I. Shreiber

SBC 2011; 81-82doi:https://doi.org/10.1115/SBC2011-53579

Topics: Finite element analysis , Kinematics , Engineering simulation , Simulation , Wounds , Biological tissues , Damage , Finite element model , Materials properties , Nervous system

The Effects of Apertures on Internal Pressure Measured During Shock Wave Exposure

Alessandra Dal Cengio Leonardi, Cynthia Bir, Dave Ritzel, Pamela VandeVord

SBC 2011; 83-84doi:https://doi.org/10.1115/SBC2011-53586

Topics: Pressure , Shock waves , Brain , Damage , Traumatic brain injury , Dynamics (Mechanics) , Military systems , Testing , Warfare

Biomechanics of Injury II

The Computational Evaluation of a Locking Plate Fixation: Locking Versus Far Cortical Screws

Mehran Moazen, Alison C. Jones, Jonathan Mak, Zhongmin Jin, Ruth K. Wilcox, Eleftherios Tsiridis

SBC 2011; 85-86doi:https://doi.org/10.1115/SBC2011-53247

Topics: Screws , Stiffness , Plates (structures) , Bone , Fracture (Materials) , Fracture (Process)

Development and Validation of an In-Vivo Finite Element Pelvis Model With Cortical Thickness Mapped From a Cadaver

Young Ho Kim, Jong-Eun Kim, Alan W. Eberhardt

SBC 2011; 87-88doi:https://doi.org/10.1115/SBC2011-53265

Topics: Finite element analysis , Bone , Finite element model , Wounds , Biomechanics , Computerized tomography , Geometry , Pelvic fractures , Radiation (Physics) , Resolution (Optics)

Wrist Kinematics and Ultrasound Measures of the Median Nerve During Computer Keyboarding

Kevin K. Toosi, Michael L. Boninger

SBC 2011; 89-90doi:https://doi.org/10.1115/SBC2011-53296

Topics: Computers , Kinematics , Ultrasound , Tunnels , Compression , Fatigue , Musculoskeletal system , Risk , Vibration

Wrapping of the Medial Ulnar Collateral Ligament

Amin M. Motlagh, Mark Carl Miller

SBC 2011; 91-92doi:https://doi.org/10.1115/SBC2011-53631

Topics: Maintenance , Soft tissues , Stability , Stress , Surgery

The Effect of Return to Overuse Activity After a Supraspinatus Tear on Joint Function and Biceps Mechanical Properties in a Rat Model

Stephen J. Thomas, Joseph J. Sarver, Jennica Tucker, Katherine Reuther, Lena Edelstein, Sarah Ilkhani-Pour, Chancellor Gray, Chang Soo Lee, David L. Glaser, Louis J. Soslowsky

SBC 2011; 93-94doi:https://doi.org/10.1115/SBC2011-53660

Topics: Mechanical properties , Tendons , Wounds

Near Side Lateral Impacts and Aortic Injury: A Parametric Study

Aditya Belwadi, King H. Yang

SBC 2011; 95-96doi:https://doi.org/10.1115/SBC2011-54019

Topics: Wounds , Aorta , Fracture (Materials) , Fracture (Process) , Cavities , Liver , Motor vehicles , Rupture , Traumatic brain injury

BioMEMS and Microfluidics

Modulation of Oxygen Tensions via Microfabricated Devices

Shawn C. Oppegard, David T. Eddington

SBC 2011; 97-98doi:https://doi.org/10.1115/SBC2011-53093

Topics: Oxygen , Biomedicine , Cancer , Glucose , Microfluidics , Sleep , Tension , Tumors

Exponential Concentration Gradients in Microfluidic Devices for Cell Studies

Šeila Selimović, Woo Young Sim, Sang Bok Kim, Yun Ho Jang, Won Gu Lee, Masoud Khabiry, Hojae Bae, Sachin Jambovane, Jong Wook Hong, Ali Khademhosseini

SBC 2011; 99-100doi:https://doi.org/10.1115/SBC2011-53529

Topics: Microfluidics , Crystallization , Microscale devices , Particulate matter , Proteins , Testing

Wide Range Logarithmic Gradient Formation for Cell Response

Morgan Hamon, Kirn Cramer, Sachin Jambovane, Jing Dai, Ali Khademhosseini, Jong Wook Hong

SBC 2011; 101-102doi:https://doi.org/10.1115/SBC2011-53710

Topics: Drugs

A Microfluidic Mixer to Activate Sperm Cells of Aquatic Species for Standardization of Computer-Assisted Motion Analysis

Daniel S. Park, Robert Egnatchik, Hali Bordelon, Terrence R. Tiersch, W. Todd Monroe

SBC 2011; 103-104doi:https://doi.org/10.1115/SBC2011-53839

Topics: Computers , Microfluidics , Biomedicine , Cryonics , Diluents , Electromagnetic induction

Digital Microfluidic Platform for 3-D Tissue Based High Throughput Screening

Subin M. George, Hyejin Moon

SBC 2011; 105-106doi:https://doi.org/10.1115/SBC2011-53995

Topics: Biological tissues , Microfluidics , Drugs , Testing , Failure , Physiology

Design of Efficient Electroosmotic Micromixer

Yogendra M. Panta, Param C. Adhikari

SBC 2011; 107-108doi:https://doi.org/10.1115/SBC2011-54005

Topics: Design , Electrodes , Fluids , Optimization , Shapes

Bio-Thermal Engineering

Reflections on Quantitative Gamma Imaging of Cell-Surface Interactions

Robert C. Eberhart

SBC 2011; 109-110doi:https://doi.org/10.1115/SBC2011-53388

Topics: Imaging , Reflection , Adhesion , Design , Diseases , Isotopes , Platelets , Proteins , Pumps , Surface science

Monte Carlo Simulation of Enhanced Laser Absorption in Tumors With Gold Nanorod Injection

Yonghui Chen, Ronghui Ma, Liang Zhu

SBC 2011; 111-112doi:https://doi.org/10.1115/SBC2011-53598

Topics: Absorption , Lasers , Nanorods , Simulation , Tumors , Nanostructures , Biological tissues , Cancer , Electromagnetic scattering , Heat conduction

Delineation of Noise Signals From MRI Measured Temperature Rise During HIFU Ablation Procedure

Subhashish Dasgupta, Seyed Ahmed Dibaji, Janaka Wansapura, Matthew R. Myers, Rupak K. Banerjee

SBC 2011; 113-114doi:https://doi.org/10.1115/SBC2011-53814

Topics: Ablation (Vaporization technology) , Magnetic resonance imaging , Noise (Sound) , Signals , Temperature , Filters , Heating , Temperature measurement , Acoustic intensity , Acoustics

Measurement and Analysis of Cutaneous Perfusion Depression During Cryotherapy

Sepideh Khoshnevis, Daniel W. Hensley, Kenneth R. Diller

SBC 2011; 115-116doi:https://doi.org/10.1115/SBC2011-53853

Topics: Biological tissues , Biomedicine , Cooling , Muscle , Musculoskeletal system , Orthopedics , Patient treatment , Sports , Surgery , Wounds

Parameter Correlation in Models of Hyperthermic Cell Death

Neil T. Wright

SBC 2011; 117-118doi:https://doi.org/10.1115/SBC2011-53933

Topics: Damage , Heating , Ionizing radiation , Temperature

Importance of Protein Denaturation to Thermochemical Ablation of Liver Tumors

Shoji Mori, Rajagopal Aravalli, Jeunghwan Choi, Erik Cressman, John Bischof

SBC 2011; 119-120doi:https://doi.org/10.1115/SBC2011-53950

Topics: Ablation (Vaporization technology) , Liver , Proteins , Tumors , Lasers , Microwaves , Patient treatment , Surgery

Biotransport Education

Appropriate Technology in an Introductory Engineering Design Experience

Alan W. Eberhardt, Richard J. Lesley, Tina G. Oliver, Rosalia N. Scripa

SBC 2011; 121-122doi:https://doi.org/10.1115/SBC2011-53011

Topics: Appropriate technology , Engineering design , Design , Biomedicine , Construction , Developing nations , Exhaust gas recirculation , Students

Biotransport Education: Thermal Therapies

John Pearce

SBC 2011; 123-124doi:https://doi.org/10.1115/SBC2011-53096

Topics: Biotransport , Education , Patient treatment , Heating , Electromagnetic fields , Heat , Heat conduction , Heat transfer , High temperature , Lasers

A Textbook and Other Resources for Teaching Challenge-Based Biotransport

Robert J. Roselli, Kenneth R. Diller

SBC 2011; 125-126doi:https://doi.org/10.1115/SBC2011-53123

Topics: Biotransport , Teaching , Bioengineering , Design , Education , Performance , Students

Education Activities of Bioengineering for Undergraduate Students at UMBC

Liang Zhu, Dwayne Arola, Charles Eggleton, Anne Spence

SBC 2011; 127-128doi:https://doi.org/10.1115/SBC2011-53149

Topics: Bioengineering , Education , Undergraduate students , Engineering disciplines , Biology , Biophysics , Chemistry , Collaboration , Diseases , Imaging

Biotransport: Fluid Mechanics, Heat and Mass Transfer

P. S. Ayyaswamy

SBC 2011; 129-130doi:https://doi.org/10.1115/SBC2011-53178

Topics: Biotransport , Fluid mechanics , Heat , Mass transfer , Students , Undergraduate students

Teaching Experience in Biotransport Course for Undergraduates of Biomedical Engineering

Lisa X. Xu, Aili Zhang

SBC 2011; 131doi:https://doi.org/10.1115/SBC2011-53379

Topics: Biomedical engineering , Biotransport , Teaching , Undergraduate students , Bioheat transfer , Heat , Mass transfer , Thermodynamics , Ablation (Vaporization technology) , Biomedicine

Biotransport in Tissue and Cellular Engineering

Effects of Freezing-Induced Cell-Fluid-Matrix Interactions on Cells and Extracellular Matrix of Engineered Tissues

Ka Yaw Teo, J. Craig Dutton, Frederick Grinnell, Bumsoo Han

SBC 2011; 133-134doi:https://doi.org/10.1115/SBC2011-53407

Topics: Biological tissues , Fluids , Freezing , Cryonics , Biomedicine , Performance , Tissue engineering

An Electromechanical Bioreactor for Scaffold-Free Skeletal Muscle Tissue Engineering

Ryan A. Koppes, Nathan R. Schiele, David T. Corr

SBC 2011; 135-136doi:https://doi.org/10.1115/SBC2011-53415

Topics: Bioreactors , Muscle , Tissue engineering , Biological tissues , Physiology , Dimensions , Diseases , Surgery , Wounds

Positive and Negative Wall Shear Stress Gradients Have Different Effects on Endothelial Phenotype Under High Wall Shear Stress

Jennifer Dolan, Frasier Sim, Hui Meng, John Kolega

SBC 2011; 137-138doi:https://doi.org/10.1115/SBC2011-53490

Topics: Shear stress , Aneurysms , Flow (Dynamics) , Hemodynamics , Vessels , Bifurcation , Blood vessels

Functionalization of Electrospun Poly (Caprolactone) to Achieve Enhanced Cell Attachment

Manisha Jassal, Shawn M. Regis, Sankha Bhowmick

SBC 2011; 139-140doi:https://doi.org/10.1115/SBC2011-53509

Topics: Biocompatibility , Biological tissues , Electrospinning , Fibers , Fibroblasts , Nanofibers , Nanoscale phenomena , Polymers , Shapes , Surface properties

Development of a 3D Microfluidic Culture Model to Study the Effect of Shear Stress on Tumor Angiogenesis

Cara F. Buchanan, Elizabeth Voigt, Christopher S. Szot, Joseph W. Freeman, Pavlos P. Vlachos, M. Nichole Rylander

SBC 2011; 141-142doi:https://doi.org/10.1115/SBC2011-53910

Topics: Microfluidics , Shear stress , Tumors , Flow (Dynamics) , Fluids , Particulate matter , Shear (Mechanics) , Three-dimensional models , Tissue engineering

Delivery of Active FGF-2 From Mechanically-Stable Biological Nanofibers Accelerates Cell Ingress Into Multifiber Composites

Jonathan A. Kluge, Rudra A. Pampati, Mara L. Schenker, Daniel J. Zhou, John E. Esterhai, David L. Kaplan, Robert L. Mauck

SBC 2011; 143-144doi:https://doi.org/10.1115/SBC2011-53955

Topics: Composite materials , Nanofibers , Fibers , Biological tissues , Polymers , Proteins , Spin (Aerodynamics) , Spinning (Textile) , Stress , Annulus

Cardiac Mechanics

A Theoretical Assessment of the Influence of Myosin Filament Dispersion on Smooth Muscle Contraction

Martin Kroon

SBC 2011; 145-146doi:https://doi.org/10.1115/SBC2011-53071

Topics: Muscle , Stress , Biological tissues , Constitutive equations , Biomechanics , Bridges (Structures) , Carotid arteries , Mechanical behavior

Analysis of Infarct Size on Myocardial Infarction Remodeling

Pei Zhang, Tieluo Li, Katrina Williams, Shuyin Li, Xufeng Wei, Hosung Son, Pablo Sanchez, Bartley P. Griffith, Zhongjun J. Wu

SBC 2011; 147-148doi:https://doi.org/10.1115/SBC2011-53117

Topics: Biomechanics , Myocardium , Stress , Wounds

A Biventricular Finite Element Model of Heart Failure for Predicting the Effects of Treatment Strategies

Jonathan F. Wenk, Liang Ge, Zhihong Zhang, Mehrdad Soleimani, D. Dean Potter, Arthur W. Wallace, Mark B. Ratcliffe, Julius M. Guccione

SBC 2011; 149-150doi:https://doi.org/10.1115/SBC2011-53142

Topics: Finite element model , Heart failure , Medical devices , Patient treatment , Statistics , Surgery , Warfare

Incorporation of Perfusion Information Into a Finite Element Model of the Left Ventricle

A. I. Veress, G. S. K. Fung, B. M. W. Tsui, W. P. Segars, G. T. Gullberg

SBC 2011; 151-152doi:https://doi.org/10.1115/SBC2011-53285

Topics: Biomedical imaging , Finite element analysis , Finite element model , Imaging , Instrumentation , Magnetic resonance imaging , Phantoms , Physics , Physiology , Simulation

Regional Mechanical Anisotropy in Decellurized Rat Heart Ventricle

Colleen Witzenburg, Ramesh Raghupathy, Stefan M. Kren, Doris A. Taylor, Victor H. Barocas

SBC 2011; 153-154doi:https://doi.org/10.1115/SBC2011-53620

Topics: Anisotropy , Biological tissues , Detergents , Endothelial cells

A Structural Constitutive Model for Right Ventricular Myocardium

Daniela Valdez-Jasso, Marc A. Simon, Michael S. Sacks

SBC 2011; 155-156doi:https://doi.org/10.1115/SBC2011-53956

Topics: Constitutive equations , Myocardium , Biomechanics , Diseases , Biological tissues , Patient treatment , Stress , Deformation , Failure , Stress-strain relations

Cardiovascular Design and Devices I

Effects of Knee Flexion on Stented Peripheral Arteries: A Computational and In Vitro Study

Ríona Ní Ghriallais, Mark Bruzzi

SBC 2011; 157-158doi:https://doi.org/10.1115/SBC2011-53224

Topics: Knee , Stents , Atherosclerosis , Biological tissues , Blood , Failure , Geometry , Muscle

Differences in Shear Stress, Residence Time and Estimates of Hemolysis Between Different Ventricular Assist Devices

Katharine H. Fraser, Tao Zhang, Bartley P. Griffith, Zhongjun J. Wu

SBC 2011; 159-160doi:https://doi.org/10.1115/SBC2011-53316

Topics: Cardiovascular system , Diseases , Heart failure , Patient treatment , Shear stress , Ventricular assist devices

Hemodynamic Performance of Oversized Flow Diverters

Fernando Mut, Juan R. Cebral

SBC 2011; 161-162doi:https://doi.org/10.1115/SBC2011-53380

Topics: Flow (Dynamics) , Hemodynamics , Stents , Aneurysms , Porosity , Surgery , Geometry , Performance , Thrombosis

Evaluation of Syncardia Total Artificial Heart Using Device Thrombogenicity Emulator

Yared Alemu, Gaurav Girdhar, Michalis Xenos, Thomas Claiborne, Jolyon Jesty, Shmuel Einav, Marvin Slepian, Danny Bluestein

SBC 2011; 163-164doi:https://doi.org/10.1115/SBC2011-53420

Topics: Artificial hearts , Platelets , Stress , Fluid structure interaction , Simulation , Cardiac cycle , Computer simulation , Computers , Density , Design

Experimental Investigation of the Local Blood Flow Pattern in Stented Coronary Bifurcations

Stefano Morlacchi, Jaime Schmieg, Dan Cooper, Francesco Burzotta, Francesco Migliavacca, Pavlos P. Vlachos

SBC 2011; 165-166doi:https://doi.org/10.1115/SBC2011-53468

Topics: Bifurcation , Blood flow , Stents , Cardiovascular system , Coronary arteries , Diseases , Endothelial cells , Hemodynamics , Shear stress , Thrombosis

Modeling Arterial Wall Transport for Drug-Eluting Stents

Franz Bozsak, Jean-Marc Chomaz, Fulvio Martinelli, Abdul I. Barakat

SBC 2011; 167-168doi:https://doi.org/10.1115/SBC2011-53871

Topics: Drugs , Modeling , Stents , Atherosclerosis , Endothelial cells , Flow (Dynamics) , Muscle , Porous materials , Stability , Thrombosis

Cardiovascular Design and Devices II

Assessment of Minimally Invasive Device That Provides Simultaneous Adjustable Cardiac Support and Active Synchronous Assist in an Acute Heart Failure Model

Michael Moreno, Saurabh Biswas, Lewis D. Harrison, Guillaume Pernelle, Matthew W. Miller, Theresa W. Fossum, David A. Nelson, John C. Criscione

SBC 2011; 169-170doi:https://doi.org/10.1115/SBC2011-53089

Topics: Heart failure , Minimally invasive devices , Diseases , Cardiovascular system , Feedback , Kinematics , Stress

Localized Cooling Device for Myocardial Tissue Salvage

Jennifer E. Akers, Denise R. Merrill, Todd J. Nilsen, Kevin J. Koomalsingh, Masahito Minakawa, Takashi Shuto, Joseph H. Gorman, III, Robert C. Gorman, Matthew J. Gillespie, Thomas L. Merrill

SBC 2011; 171-172doi:https://doi.org/10.1115/SBC2011-53155

Topics: Biological tissues , Blood flow , Cascades (Fluid dynamics) , Cooling , Flow (Dynamics) , Patient treatment , Salvage (Wastes) , Wounds

Design Optimization of Rotary Blood Pumps: Alternatives to Anticoagulation Therapy

Gaurav Girdhar, Michalis Xenos, Wei-Che Chiu, Yared Alemu, Bryan Lynch, Jolyon Jesty, Marvin Slepian, Shmuel Einav, Danny Bluestein

SBC 2011; 173-174doi:https://doi.org/10.1115/SBC2011-53171

Topics: Blood , Design , Optimization , Patient treatment , Pumps , Platelets , Bridges (Structures) , Computer simulation , Flow (Dynamics) , Heart failure

Mechanical Flow Restoration in Acute Ischemic Stroke: A Model System of Cerebrovascular Occlusion

J. Y. Chueh, A. K. Wakhloo, M. J. Gounis

SBC 2011; 175-176doi:https://doi.org/10.1115/SBC2011-53172

Topics: Biological tissues , Blood flow , Flow (Dynamics) , Food and Drug Administration , Frequency-domain analysis , Patient treatment , Performance , Risk

Fluid Study of Transcatheter Aortic Valve Deployment Into Patients With Varying Coronary Ostia Position

Eric Sirois, Qian Wang, Susheel Kodali, Wei Sun

SBC 2011; 177-178doi:https://doi.org/10.1115/SBC2011-53891

Topics: Fluids , Valves , Flow (Dynamics) , Computational fluid dynamics , Coronary arteries , Finite element analysis , Computerized tomography , Dimensional analysis , Dimensions , Hemodynamics

Radiofrequency Ablation With a Cryogenically Cooled Catheter to Percutaneously Treat Mitral Valve Prolapse

Steven M. Boronyak, W. David Merryman

SBC 2011; 179-180doi:https://doi.org/10.1115/SBC2011-53911

Topics: Catheters , Radiofrequency ablation , Valves , Diseases , Flow (Dynamics) , Surgery

Cardiovascular Diagnostics

Assessment of Aortic Graft Impact on Hemodynamics

Orestis Vardoulis, Eline Coppens, Bryn Martin, Philippe Reymond, Nikos Stergiopulos

SBC 2011; 181-182doi:https://doi.org/10.1115/SBC2011-53245

Topics: Hemodynamics , Pressure , Waves , Reflectance , Blood , Flow (Dynamics) , Physiology , Reflection , Stress

A 1D Wave Propagation Model of Coronary Flow in a Beating Heart

Arjen van der Horst, Frits L. Boogaard, Marcel C. M. Rutten, Frans N. van de Vosse

SBC 2011; 183-184doi:https://doi.org/10.1115/SBC2011-53367

Topics: Coronary arteries , Diseases , Flow (Dynamics) , Flow measurement , Myocardium , Pressure , Sensors , Vessels , Wave propagation , Wire

The Parametrized Diastolic Filling Formalism: Application in the Asklepios Population

Tom Claessens, Muhammad Waheed Raja, Antoine Pironet, Julio Chirinos, Thomas Desaive, Ernst Rietzschel, Marc De Buyzere, Peter Van Ransbeeck, Pascal Verdonck, Thierry Gillebert, Patrick Segers

SBC 2011; 185-186doi:https://doi.org/10.1115/SBC2011-53375

Topics: Damping , Displacement , Kinematics , Relaxation (Physics) , Springs , Stiffness

Impedance to Cerebrospinal Fluid Flow in the Cervical Spinal Canal is Dominated by Geometric Complexity

Nicholas Shaffer, Francis Loth, Oliver Wieben, Brandon Rocque, Bermans Iskandar, John Oshinski

SBC 2011; 187-188doi:https://doi.org/10.1115/SBC2011-53642

Topics: Canals , Cerebrospinal fluid , Flow (Dynamics) , Fluids , Geometry , Mechanical properties , Nervous system , Physiology , Surgery

Impact of Aortic Prosthetic Heart Valve Dysfunction on Left Ventricular Afterload and on the Accuracy of Echo-Doppler Measurements

Othman Smadi, Zahra Keshavarz-Motamed, Ibrahim Hassan, Philippe Pibarot, Lyes Kadem

SBC 2011; 189-190doi:https://doi.org/10.1115/SBC2011-53769

Topics: Echoes , Heart valve prostheses , Valves , Blood , Artificial limbs , Coagulants (Materials) , Design , Diseases , High pressure (Physics) , Surgery

Assessment of Right Ventricular Inefficiency Using Energy Transfer Ratio in Repaired Tetralogy of Fallot

Namheon Lee, Ashish Das, William M. Gottliebson, Rupak K. Banerjee

SBC 2011; 191-192doi:https://doi.org/10.1115/SBC2011-53965

Topics: Energy transformation , Pressure , Pulmonary artery , Statistical analysis , Surgery

Cardiovascular Tissue Engineering

The Potential of Prolonged Tissue Culture to Reduce Stress Generation and Retraction in Engineered Heart Valve Tissues

Marijke A. A. van Vlimmeren, Anita Driessen-Mol, Cees W. J. Oomens, Frank P. T. Baaijens

SBC 2011; 193-194doi:https://doi.org/10.1115/SBC2011-53120

Topics: Biological tissues , Stress , Valves , Traction , Compacting , Tissue engineering

Anchorage: Dependent Persistent Alignment of Perfused Microvasculature in Implanted Tissue Constructs

Laxminarayanan Krishnan, Carlos C. Chang, Shawn Reese, Stuart K. Williams, Jeffrey A. Weiss, James B. Hoying

SBC 2011; 195-196doi:https://doi.org/10.1115/SBC2011-53630

Topics: Anchorage , Biological tissues , Flow (Dynamics) , Bioprinting , Blood flow , Printing , Vessels

Optimizing a Three Layered Electrospun Matrix to Mimic Native Arterial Architecture: Cellular and Mechanical Analysis

Michael J. McClure, Scott A. Sell, David G. Simpson, Beat H. Walpoth, Gary L. Bowlin

SBC 2011; 197-198doi:https://doi.org/10.1115/SBC2011-53689

Topics: Adhesion , Aorta , Biomechanics , Biopolymers , Blood flow , Deformation , Elasticity , Endothelial cells , Fibroblasts , Heat

Self-Assembling Peptide Nanofibers for MMP Delivery and Cardiac Regeneration in Diabetes

Jennifer R. Hurley, Abdul Q. Sheikh, Meredith Beckenhaupt, Cameron Ingram, Andrew Mutchler, Daria A. Narmoneva

SBC 2011; 199-200doi:https://doi.org/10.1115/SBC2011-53761

Topics: Diabetes , Nanofibers , Self-assembly , Fibroblasts , Myocardium , Biomedicine , Cardiovascular system , Proteins

Diabetes Alters Intracellular Calcium Transients in Cardiac Endothelial Cells

Abdul Q. Sheikh, Jennifer R. Hurley, Daria A. Narmoneva

SBC 2011; 201-202doi:https://doi.org/10.1115/SBC2011-53797

Topics: Diabetes , Endothelial cells , Transients (Dynamics) , Myocardium , Pumps , Membranes

A Strain Energy-Based Constitutive Model for Continuous-Fiber Tissue Engineered Valved Conduit Tissue

Chad E. Eckert, Michael S. Sacks

SBC 2011; 203-204doi:https://doi.org/10.1115/SBC2011-53967

Topics: Biological tissues , Constitutive equations , Fibers , Composite materials , Deformation , Mechanical properties , Modeling , Tissue engineering , Valves

Cartilage/Disc Mechanics

A Comparison of the Mechanical Properties of the Goat Temporomandibular Joint Disc to the Mandibular Condylar Cartilage in Unconfined Compression

Catherine K. Hagandora, Alejandro J. Almarza

SBC 2011; 205-206doi:https://doi.org/10.1115/SBC2011-53173

Topics: Cartilage , Compression , Disks , Mechanical properties , Biological tissues , Bone , Tissue engineering

Magnetic Resonance Elastography for the Measurement of Annulus Fibrosus Material Properties

Daniel H. Cortes, Lachlan J. Smith, Sung M. Moon, Jeremy F. Magland, Alexander C. Wright, Dawn M. Elliott

SBC 2011; 207-208doi:https://doi.org/10.1115/SBC2011-53436

Topics: Annulus , Elastography , Magnetic resonance , Materials properties , Mechanical properties , Disks , Anisotropy , Fibers , Magnetic resonance imaging , Shear modulus

Finite Element Implementation of Neutral Solute Transport in Porous Biological Soft Tissues Under Finite Deformation

Gerard A. Ateshian, Michael B. Albro, Steve Maas, Jeffrey A. Weiss

SBC 2011; 209-210doi:https://doi.org/10.1115/SBC2011-53477

Topics: Deformation , Finite element analysis , Soft tissues , Anisotropy , Biological tissues , Biomechanics , Fluids , Modeling , Momentum , Physiology

Local Shear Deformation in Whole Cartilage Explants Determined by Texture Correlation

Jonathan T. Henderson, Garrett Shannon, Kai Yuen, Corey P. Neu

SBC 2011; 211-212doi:https://doi.org/10.1115/SBC2011-53496

Topics: Cartilage , Shear deformation , Texture (Materials) , Compression , Diseases , Osteoarthritis , Shear (Mechanics) , Wear

Evaluation of Wrist Cartilage With and Without Scapholunate Ligament Injury in Pre and Post Operation Subjects

Dannica L. Sturgeon, Sang-Pil Lee, Terence E. McIff, E. Bruce Toby, Kenneth J. Fischer

SBC 2011; 213-214doi:https://doi.org/10.1115/SBC2011-53718

Topics: Cartilage , Wounds , Osteoarthritis , Collapse , Surgery

Detection of MMP-13 Activity on Intentionally Strain-Released Type-II Collagen Network in Bovine Articular Cartilage

Nazli Caner, Jeffrey W. Ruberti

SBC 2011; 215-216doi:https://doi.org/10.1115/SBC2011-53913

Topics: Cartilage , Biological tissues , Enzymes , Tension , Proteins , Density , Maintenance , Osteoarthritis , Water

CFD Modeling and Applications

Hemodynamic Compromise During Carotid Angioplasty and Stenting

A. G. Lynch, M. T. Walsh

SBC 2011; 217-218doi:https://doi.org/10.1115/SBC2011-53441

Topics: Hemodynamics , Carotid arteries , Diseases , Surgery , Blood , Blood flow , Brain , Nervous system

Framework for Fluid-Structure Interaction Analysis of Aortic Coarctation Resulting From Proximal Protusion of Thoracic Aortic Stent Graft Into the Arch

Salvatore Pasta, Onur Dur, Jae-Sung Cho, Kerem Pekkan, David A. Vorp

SBC 2011; 219-220doi:https://doi.org/10.1115/SBC2011-53602

Topics: Arches , Fluid structure interaction , Stents , Collapse , Maintenance , Diseases , Aorta , Aortic arch , Blood , Flow (Dynamics)

Smoothed Particle Hydrodynamics Simulation of Flow Through a Bileaflet Mechanical Heart Valve: Advantages and Prospects

Shahrokh Shahriari, Hoda Maleki, Ibrahim Hassan, Lyes Kadem

SBC 2011; 221-222doi:https://doi.org/10.1115/SBC2011-53879

Topics: Flow (Dynamics) , Heart valve prostheses , Hydrodynamics , Particulate matter , Simulation , Blood , Computer simulation , Fluids , Hemodynamics , Mesh generation

Nitric Oxide Transport in Lymphatic Vessels

John T. Wilson, Rebecca L. Dahlin, Olga Gasheva, David C. Zawieja, James E. Moore, Jr.

SBC 2011; 223-224doi:https://doi.org/10.1115/SBC2011-53886

Topics: Biological tissues , Cancer , Filtration , Fluids , Particulate matter , Physiology , Proteins , Space , Vessels

Pulsatile Hemodynamics of the Fontan Connection: A Tri-Modal Investigation

Christopher M. Haggerty, Diane A. de Zélicourt, Jessica R. Kanter, Kartik S. Sundareswaran, Mark A. Fogel, Ajit P. Yoganathan

SBC 2011; 225-226doi:https://doi.org/10.1115/SBC2011-53890

Topics: Hemodynamics , Imaging , Pulsatile flow

Grand Challenge Competition to Predict In Vivo Knee Loads

A Weighted Objective Function Reduces Estimates of Medial and Lateral Knee Joint Contact Loads During Gait

S. C. E. Brandon, D. G. Thelen, K. J. Deluzio

SBC 2011; 227-228doi:https://doi.org/10.1115/SBC2011-53594

Topics: Knee , Stress , Degrees of freedom , Electromyography , Kinematics , Muscle , Soft tissues , Weight (Mass)

Introduction of Contact Forces Minimization in the Musculo-Tendon Forces Optimization During Gait

Florent Moissenet, Laurence Cheze, Raphaël Dumas

SBC 2011; 229-230doi:https://doi.org/10.1115/SBC2011-53650

Topics: Optimization , Tendons , Computation , Simulation

A Musculoskeletal Model With Prosthetic Knee During a Walk Cycle

Mohammad Kia, Trent M. Guess

SBC 2011; 231-232doi:https://doi.org/10.1115/SBC2011-53940

Topics: Artificial limbs , Cycles , Knee , Musculoskeletal system , Muscle , Biological tissues , Contact mechanics , Engineering simulation , Hinges , Simulation

Dual-Joint Modeling for Estimation of Total Knee Replacement Contact Forces During Locomotion

Michael W. Hast, Stephen J. Piazza

SBC 2011; 233-234doi:https://doi.org/10.1115/SBC2011-53948

Topics: Arthroplasty , Contact mechanics , Cycles , Design , Experimental methods , Knee joint prostheses , Modeling , Stress , Surgery

Heart Valve Mechanobiology

Discovery of Side- and Shear-Dependent miRNAs and mRNAs in Human Aortic Valvular Endothelial Cells

Casey J. Holliday, Randall F. Ankeny, Hanjoong Jo, Robert M. Nerem

SBC 2011; 235-236doi:https://doi.org/10.1115/SBC2011-53315

Topics: Endothelial cells , Shear (Mechanics) , Diseases , Flow (Dynamics) , Cardiovascular system , Maintenance , Surgery , Valves

Physiological Micromechanics of the Anterior Mitral Valve Leaflet

Christopher A. Carruthers, Bryan Good, Antonio D’Amore, Rouzbeh Amini, Joseph H. Gorman, Michael S. Sacks

SBC 2011; 237-238doi:https://doi.org/10.1115/SBC2011-53637

Topics: Micromechanics (Engineering) , Physiology , Valves , Fibers , Deformation , Stress , Biological tissues , Diseases , Mechanical properties , Patient treatment

Evaluation of Acellular Mitral Valve Scaffolds: Anterior Leaflet, Posterior Leaflet, and Chordae Tendineae

Bo Wang, Dustin McCallum, Lakiesha Williams, Jun Liao

SBC 2011; 239-240doi:https://doi.org/10.1115/SBC2011-53668

Topics: Valves , Biological tissues , Diseases , Durability , Maintenance , Blood flow , Heart valve prostheses , Pediatrics , Surgery , Tissue engineering

Biomechanical Analysis of Embryonic Atrioventricular Valvulogenesis

Philip R. Buskohl, Russell A. Gould, Jonathan T. Butcher

SBC 2011; 241-242doi:https://doi.org/10.1115/SBC2011-53791

Topics: Biomechanics , Valves , Biological tissues , Cellular mechanics , Materials properties , Mechanical testing , Testing

Calcific Nodule Morphogenesis by Aortic Valve Interstitial Cells: Synergism of Applied Strain and TGF-β1

Joseph Chen, Charles I. Fisher, M. K. Sewell-Loftin, W. David Merryman

SBC 2011; 243-244doi:https://doi.org/10.1115/SBC2011-53899

Topics: Valves , Diseases , Stiffness , Cardiovascular system , Osteoblasts

Low and Unsteady Shear Stresses Upregulate Calcification Response of the Aortic Valve Leaflets

Swetha Rathan, Choon Hwai Yap, Elizabeth Morris, Sivakkumar Arjunon, Hanjoong Jo, Ajit P. Yoganathan

SBC 2011; 245-246doi:https://doi.org/10.1115/SBC2011-53946

Topics: Shear stress , Valves , Diseases , Hemodynamics , Biological tissues , Failure , Fluids , Membranes , Pressure , Tension

Heart Valves: Leaflet and Annulus Mechanics

Tricuspid Valve Annulus Tension

Shamik Bhattacharya, Zhaoming He

SBC 2011; 247-248doi:https://doi.org/10.1115/SBC2011-53088

Topics: Annulus , Tension , Valves , Geometry , Displacement , Muscle , Performance , Pressure , Shapes

In-Vivo Dynamic Strains of the Ovine Anterior Mitral Valve Leaflet

Manuel Rausch, Wolfgang Bothe, John-Peder Escobar-Kvitting, Serdar Goktepe, Craig Miller, Ellen Kuhl

SBC 2011; 249-250doi:https://doi.org/10.1115/SBC2011-53195

Topics: Valves , Deformation , Maintenance , Surgery , Cardiac cycle , Hemodynamics

Effect of Aortic Distensibility on Coronary Flow: A 3D FSI Model of Aortic Valve With the Inclusion of Coronary Arteries

Soroush Nobari, Rosaire Mongrain, Richard Leask, Raymond Cartier

SBC 2011; 251-252doi:https://doi.org/10.1115/SBC2011-53487

Topics: Coronary arteries , Flow (Dynamics) , Fluid structure interaction , Valves , Aneurysms , Blood flow , Hemodynamics , Myocardium , Oxygen , Pressure

Simulations of Flow Through Bileaflet Mechanical Heart Valves to Assess Platelet Damage

B. Min Yun, Jingshu Wu, Cyrus K. Aidun, Ajit P. Yoganathan

SBC 2011; 253-254doi:https://doi.org/10.1115/SBC2011-53842

Topics: Damage , Engineering simulation , Flow (Dynamics) , Heart valve prostheses , Platelets , Simulation , Blood , Design , Stress , Hemodynamics

Simulated Deployment of Percutaneous Transvenous Mitral Annuloplasty Device Into Human Coronary Sinus Vessel

Thuy M. Pham, Qian Wang, Milton DeHerrera, Wei Sun

SBC 2011; 255-256doi:https://doi.org/10.1115/SBC2011-53851

Topics: Vessels , Surgery , Annulus , Biomechanics , Diseases , Finite element analysis , Fracture (Materials) , Fracture (Process) , Maintenance , Performance

Functional Dynamic In-Vivo Stresses of the Mitral Valve Anterior Leaflet

Rouzbeh Amini, Chad E. Eckert, Christopher A. Carruthers, Kevin Koomalsingh, Mashito Minakawa, Robert C. Gorman, Joseph H. Gorman, Michael S. Sacks

SBC 2011; 257-258doi:https://doi.org/10.1115/SBC2011-53925

Topics: Stress , Valves , Biological tissues , Constitutive equations , Damage , Durability , Failure , Failure mechanisms , Maintenance , Surgery

Hemodynamics of Aneurysms

Direct Numerical Simulation of Transitional Flow in a Patient-Specific MCA Aneurysm

Kristian Valen-Sendstad, Kent-Andre Mardal, Mikael Mortensen, Bjørn A. P. Reif, Hans Petter Langtangen

SBC 2011; 259-260doi:https://doi.org/10.1115/SBC2011-53306

Topics: Aneurysms , Computer simulation , Flow (Dynamics) , Rupture , Brain , Endothelial cells , Risk , Shear stress

Longitudinal Image Based Study of Cerebral Aneurysms: Growth, Contacts and Hemodynamics During Aneurysmal Progression

Juan R. Cebral, Daniel Sforza, Satoshi Tateshima, Fernando Vinuela, Christopher Putman

SBC 2011; 261-262doi:https://doi.org/10.1115/SBC2011-53382

Topics: Aneurysms , Hemodynamics , Biology , Biomechanics , Bone , Imaging , Rupture

Steady Versus Pulsatile Flow Modeling for Hemodynamics Based Stratification of a Population of Intracranial Aneurysms

Rohini Retarekar, Benjamin Berkowitz, Madhavan L. Raghavan

SBC 2011; 263-264doi:https://doi.org/10.1115/SBC2011-53503

Topics: Aneurysms , Hemodynamics , Modeling , Pulsatile flow , Engineering simulation , Simulation , Computational fluid dynamics , Shapes , Blood flow , Boundary-value problems

An Experimental Study of the Effects Anatomical Variations Have on Collateral Flows Within the Circle of Willis

Paul Fahy, Patrick Delassus, Padraig O’Flynn, Liam Morris

SBC 2011; 265-266doi:https://doi.org/10.1115/SBC2011-53723

Topics: Flow (Dynamics) , Blood , Blood flow , Brain , Cerebral arteries , Collisions (Physics) , Oxygen , Vessels

Hemodynamics of Elastase-Induced Aneurysms in Rabbit: A New High Flow Bifurcation Model

Zijing Zeng, David F. Kallmes, Yong Hong Ding, Ramanathan Kadirvel, Debra A. Lewis, D. Dai, Anne M. Robertson

SBC 2011; 267-268doi:https://doi.org/10.1115/SBC2011-53819

Topics: Aneurysms , Bifurcation , Flow (Dynamics) , Hemodynamics , Rupture , Biomechanics , Cerebral arteries , Risk , Shapes , Stress

Comparison of Normal and Pathological Hemodynamics in Coronary Artery Aneurysms Caused by Kawasaki Disease

Dibyendu Sengupta, Jane C. Burns, Andrew Kahn, Alison L. Marsden

SBC 2011; 269-270doi:https://doi.org/10.1115/SBC2011-53864

Topics: Aneurysms , Coronary arteries , Diseases , Hemodynamics , Blood flow , Engineering simulation , Risk , Risk assessment , Simulation , Thrombosis

Human Dynamics

Neck Muscle Strength Measured During Vigorous Head Shaking

James R. Funk, Richard A. Watson, Joseph M. Cormier, Charles E. Bain, Herb Guzman, Enrique Bonugli

SBC 2011; 271-272doi:https://doi.org/10.1115/SBC2011-53193

Topics: Muscle , Tension , Inertia (Mechanics) , Sports , Wounds

Improved Simulation of Heel Contact During Normal Walking

Arash Mahboobin, Rakié Cham, Stephen J. Piazza

SBC 2011; 273-274doi:https://doi.org/10.1115/SBC2011-53453

Topics: Simulation , Biomechanics , Computer simulation , Dynamic systems , Dynamics (Mechanics) , Human factors

A Robust Real-Time Control Algorithm for Whole-Body Running

Xianlian Zhou, Andrzej Przekwas

SBC 2011; 275-276doi:https://doi.org/10.1115/SBC2011-53458

Topics: Algorithms , Biomechanics , Computers , Defense industry , Experimental methods , Mechanical admittance , Real-time control , Redundancy (Engineering) , Simulation

A Surface-to-Surface Contact Model for Multibody Dynamics Modelling of the Human Hip

Adam Stops, Ruth Wilcox, Zhongmin Jin

SBC 2011; 277-278doi:https://doi.org/10.1115/SBC2011-53475

Topics: Modeling , Multibody dynamics , Cartilage , Deformation , Engineering simulation , Simulation , Degrees of freedom , Finite element analysis , Joint mechanics , Mechanical properties

Dynamic Trunk Control Influence on Run-to-Cut Maneuver: A Risk Factor for ACL Rupture

Steve T. Jamison, Xueliang Pan, Ajit M. W. Chaudhari

SBC 2011; 279-280doi:https://doi.org/10.1115/SBC2011-53697

Topics: Anterior cruciate ligament , Risk , Rupture , Wounds , Knee , Osteoarthritis , Physiology , Rotation , Sports , Stress

A Spring-Mass Model of Locomotion With Full Asymptotic Stability

Zhuohua Shen, Justin Seipel

SBC 2011; 281-282doi:https://doi.org/10.1115/SBC2011-53973

Topics: Springs , Stability , Pendulums , Center of mass , Clocks , Dynamics (Mechanics) , Flight , Legged locomotion , Robots

Material and Structural Characterization of Bone

Functional Imaging of the Proximal Femur Using Shape Template and a Bone Mineral Density Image

Sami P. Väänänen, Hanna Isaksson, Jukka S. Jurvelin

SBC 2011; 283-284doi:https://doi.org/10.1115/SBC2011-53103

Topics: Bone , Density , Imaging , Minerals , Shapes , Finite element analysis , Fracture (Materials) , Fracture (Process) , Risk , Bone mechanics

Creep Simulation of a Micro-CT Based Finite Element Model of Porcine Cancellous Bone

Ahmet H. Ertas, Betty J. Sindelar, John R. Cotton

SBC 2011; 285-286doi:https://doi.org/10.1115/SBC2011-53320

Topics: Bone , Creep , Finite element model , Simulation , Fatigue , Deformation , Failure , Fracture (Materials) , Fracture (Process) , Mechanical testing

Indentation Simulation of Ovariectomized Sheep Bone Using a Viscoelastic/Plastic Damage Model

Yang Zhao, Timothy C. Ovaert

SBC 2011; 287-288doi:https://doi.org/10.1115/SBC2011-53351

Topics: Bone , Damage , Simulation , Fracture (Materials) , Mechanical behavior , Mechanical properties , Microcracks , Modeling , Nanoindentation , Optical microscopes

Cervical Spine Bone Mineral Density as a Function of Vertebral Level and Anatomic Location

Eric Thorhauer, William Anderst, William Donaldson, Joon Lee, James Kang

SBC 2011; 289-290doi:https://doi.org/10.1115/SBC2011-53698

Topics: Bone , Cervical spine , Density , Minerals , Computerized tomography , Mechanical properties , Finite element model , Instrumentation , Stiffness , Stress

The Effects of a Functionally Graded Cellular Structure on Impact Properties of a Hip Joint: A Finite Element Study

T. Kara, S. Takak, M. Ali, J. Hoffman

SBC 2011; 291-292doi:https://doi.org/10.1115/SBC2011-53768

Topics: Arthroplasty , Ceramics , Finite element analysis , Hip joint prostheses , Kinematics , Metals , Wear

Shear Strain of Mineral Crystals Calculated Using Wide-Angle X-Ray Scattering (WAXS) Techniques

Bijay Giri, X. Neil Dong, Jon D. Almer, Xiaodu Wang

SBC 2011; 293-294doi:https://doi.org/10.1115/SBC2011-53927

Topics: Crystals , Electromagnetic scattering , Minerals , Radiation scattering , Scattering (Physics) , Shear (Mechanics) , X-rays , Bone , Biological tissues , Deformation

Mechanical Circulatory Support

A Particle Image Velocimetry Study of the Penn State 50cc Left Ventricular Assist Device: The Impact of Varying Heart Rate

Michael A. Navitsky, Jason C. Nanna, Stephen R. Topper, Steven Deutsch, Keefe B. Manning

SBC 2011; 295-296doi:https://doi.org/10.1115/SBC2011-53207

Topics: Particulate matter , Ventricular assist devices , Heart failure , Bridges (Structures) , Cavities , Patient treatment , Thrombosis

In Silico Design and In-Vivo Analysis of the Pediaflow™ Pediatric Ventricular Assist Device

Timothy M. Maul, James F. Antaki, Jingchun Wu, Jeongho Kim, Marina V. Kameneva, Salim E. Olia, Peter D. Wearden, Ergin Kocylidirim, Harvey S. Borovetz

SBC 2011; 297-298doi:https://doi.org/10.1115/SBC2011-53241

Topics: Design , Pediatrics , Ventricular assist devices , Engineering prototypes , Pumps , Biocompatibility , Blood , Computational fluid dynamics , Engineering simulation , Flow (Dynamics)

Development, Pre-Clinical Validation of the UltraMag and Summary of the Clinical Experience With Levitronix Ventricular Assist System

Barry N. Gellman, J. Scott Richardson, Egemen Tuzun, Thomas M. Gempp, Kelly M. Harms, Andreas Fleischli, Kimberly S. Moody, John D. Marks, Jeff L. Conger, Stella Kent, O. Howard Frazier, Kurt A. Dasse

SBC 2011; 299-300doi:https://doi.org/10.1115/SBC2011-53585

Topics: Magnetic levitation , Pediatrics , Ventricular assist devices

Multi-Laboratory Uncertainty Analysis of PIV-Measured Flow Quantities Relevant to Blood Damage in the FDA Nozzle Model

Prasanna Hariharan, Matthew Giarra, Varun Reddy, Steven W. Day, Keefe B. Manning, Steven Deutsch, Matthew R. Myers, Sandy F. C. Stewart, Greg W. Burgreen, Eric G. Paterson, Richard A. Malinauskas

SBC 2011; 301-302doi:https://doi.org/10.1115/SBC2011-53644

Topics: Blood , Damage , Flow (Dynamics) , Food and Drug Administration , Frequency-domain analysis , Nozzles , Uncertainty analysis , Computational fluid dynamics , Shear (Mechanics) , Uncertainty

Novel Extra Aortic Counterpulsation Device for Enhancing Cardiac Performance

Peter W. Walsh, Craig McLachlan, Leigh Ladd, R. Mark Gillies

SBC 2011; 303-304doi:https://doi.org/10.1115/SBC2011-53699

Topics: Aorta , Atherosclerosis , Blood flow , Cardiovascular system , Coronary arteries , Diseases , Heart failure , Pressure , Pumps , Stiffness

Assessment of Cardiac Function During Mechanical Circulatory Support: A Simulation Study

Antonio Ferreira, Yajuan Wang, John Gorcsan, III, James F. Antaki

SBC 2011; 305-306doi:https://doi.org/10.1115/SBC2011-53735

Topics: Heart failure , Simulation , Ventricular assist devices

Mechanoregulation of Bone: A Tribute to Rik Huiskes

Progressive Subchondral Sclerosis During OA Explained by Depth-Dependent Bone Demineralization

L. G. E. Cox, B. van Rietbergen, C. C. van Donkelaar, K. Ito

SBC 2011; 307-308doi:https://doi.org/10.1115/SBC2011-53473

Topics: Bone , Patient treatment , Cartilage , Drugs , Materials properties , Osteoarthritis

Altered Mechanosensitivity Can Explain the Substantially Increased Bone Mass in Hypoparathyroidism

Patrik Christen, Bert van Rietbergen, Keita Ito

SBC 2011; 309-310doi:https://doi.org/10.1115/SBC2011-53485

Topics: Bone

Simulation of the Emergence of the Endochondral Ossification Process in Evolution

Hanifeh Khayyeri, Patrick J. Prendergast

SBC 2011; 311-312doi:https://doi.org/10.1115/SBC2011-53714

Topics: Biological tissues , Bone , Musculoskeletal system , Simulation

Bone Biomechanical Behavior in Adult Mice is Regulated by Osteoblast Gi Signaling in a Sex- and Site-Specific Manner

Aaron J. Fields, Susan M. Millard, Jeannie F. Bailey, Dylan O’Carroll, Jeffrey C. Lotz, Robert A. Nissenson

SBC 2011; 313-314doi:https://doi.org/10.1115/SBC2011-53773

Topics: Biomechanics , Bone , Osteoblasts , Osteoporosis , Maintenance , Mechanical behavior , Patient treatment , Proteins , Stiffness

Shear Stress Within Trabecular Bone Marrow due to Low Magnitude High Frequency Vibration

Thomas R. Coughlin, Laoise M. McNamara, Peter E. McHugh, Glen L. Niebur

SBC 2011; 315-316doi:https://doi.org/10.1115/SBC2011-53803

Topics: Bone , Shear stress , Vibration , Signals

Induced Intramedullary Pressure by Dynamic Hydraulic Stimulation and Its Potential in Attenuation of Bone Loss

M. Hu, J. Cheng, S. Ferreri, F. Serra-Hsu, W. Lin, Y. X. Qin

SBC 2011; 317-318doi:https://doi.org/10.1115/SBC2011-54015

Topics: Bone , Pressure , Fluid dynamics , Astronauts , Osteoporosis , Signals

Mechanotransduction and Sub-Cellular Biophysics I

In Situ Observation of Nuclear Behavior During Laser Nano-Dissection of Actin Stress Fibers: Mechanical Interaction Between Actin Stress Fibers and Nucleus

Kazuaki Nagayama, Yuki Yahiro, Takeo Matsumoto

SBC 2011; 319-320doi:https://doi.org/10.1115/SBC2011-53264

Topics: Fibers , Lasers , Stress , Structural mechanics , Membranes , Proteins

The Roles of HS and Its Glypican-1 Core Protein in Flow-Induced Endothelial NOS Activation and Cell Remodeling

E. E. Ebong, D. C. Spray, J. M. Tarbell

SBC 2011; 321-322doi:https://doi.org/10.1115/SBC2011-53294

Topics: Flow (Dynamics) , Proteins , Shear (Mechanics) , Diseases , Endothelial cells , RNA , Shear stress

Differentiation and Dynamic Tensile Loading Alter Nuclear Mechanics and Mechanoreception in Mesenchymal Stem Cells

Su-Jin Heo, Nandan L. Nerurkar, Tristan P. Driscoll, Robert L. Mauck

SBC 2011; 323-324doi:https://doi.org/10.1115/SBC2011-53432

Topics: Stem cells , Deformation , Nanofibers , Biological tissues , Cellular mechanics , Machinery , Proteins , Shapes , Signals , Stiffness

Engineering Tools for Studying Coordination Between Biochemical and Biomechanical Activities in Cell Migration

Sungsoo Na

SBC 2011; 325-326doi:https://doi.org/10.1115/SBC2011-53709

Topics: Biomechanics , Engineering instruments , Stiffness , Dynamics (Mechanics) , Traction , Adhesion , Biosensors , Energy transformation , Feedback , Fluorescence

A Multiscale Model of Cell Adhesion and Migration on Extracellular Matrices of Defined Stiffness and Adhesivity

Amit Pathak, Sanjay Kumar

SBC 2011; 327-328doi:https://doi.org/10.1115/SBC2011-53757

Topics: Adhesion , Stiffness , Adhesives , Density , Manufacturing , Signals , Tumors

Dynamics of Membrane Rafts, Talin, and Actin at Nascent and Mechanically Perturbed Focal Adhesions

Daniela E. Fuentes, Peter J. Butler

SBC 2011; 329-330doi:https://doi.org/10.1115/SBC2011-54027

Topics: Adhesion , Dynamics (Mechanics) , Membranes

Mechanotransduction and Sub-Cellular Biophysics II

Oscillatory Fluid Flow Affects the Osteogenic Differentiation of Human Bone Marrow Stromal Cells in a Primary Cilium Dependent Manner

David A. Hoey, Christopher R. Jacobs

SBC 2011; 331-332doi:https://doi.org/10.1115/SBC2011-53435

Topics: Bone , Fluid dynamics , Cavities , Diseases , Hydrostatic pressure , Osteoblasts , Osteoporosis , Shear stress

Mechanically Induced Calcium Release From Bone Matrix Triggers Intracellular Ca²⁺ Signalling in Osteoblasts: A Novel Mechanotransduction Mechanism

Xuanhao Sun, Vipuil Kishore, Kateri Fites, Ozan Akkus

SBC 2011; 333-334doi:https://doi.org/10.1115/SBC2011-53446

Topics: Bone , Osteoblasts , Damage , Maintenance , Signals , Deformation , Fluid dynamics , Hydrostatic pressure , Microcracks , Shear (Mechanics)

Remodeling and Contractility of the Actin Cytoskeleton During the Shear Deformation of Single Chondrocytes

Enda P. Dowling, William Ronan, Vikram S. Deshpande, Robert M. McMeeking, Kyriacos A. Athanasiou, J. Patrick McGarry

SBC 2011; 335-336doi:https://doi.org/10.1115/SBC2011-53600

Topics: Chondrocytes , Shear deformation , Agar , Compression , Polymerization , Stress

The Role of SRC in Strain- and Ligand- Dependent Phenotypic Modulation of Mouse Embryonic Fibroblasts

M. K. Sewell-Loftin, W. David Merryman

SBC 2011; 337-338doi:https://doi.org/10.1115/SBC2011-53604

Topics: Fibroblasts , Biological tissues , Diseases , Proteins , Atherosclerosis , Construction , Muscle , Patient treatment , Stiffness , Valves

How Do Cells Sense Substrate Stiffness? Effects of Substrate Elasticity and Thickness on the Behavior of Rat Aortic Smooth Muscle Cells

Takeo Matsumoto, Norihiro Matsui, Mai Ishiguro, Kazuaki Nagayama

SBC 2011; 339-340doi:https://doi.org/10.1115/SBC2011-53811

Topics: Elasticity , Muscle , Stiffness , Surface mount components , Adhesion , Biology , Stem cells

Cyclic Strain and Interstitial Flow Modulate Cardiac Fibroblast Phenotype Through Angiotensin II and TGF-β Pathways

Peter A. Galie, Jan P. Stegemann

SBC 2011; 341-342doi:https://doi.org/10.1115/SBC2011-53924

Topics: Fibroblasts , Flow (Dynamics) , Fluid dynamics , Myocardium

Mechanotransduction and Sub-Cellular Biophysics III

Adipocytes Respond to Mechanical Stretch by Producing More Lipids

Naama Shimon, Orna Shaharabani-Yosef, Uri Zaretsky, Amit Gefen

SBC 2011; 343-344doi:https://doi.org/10.1115/SBC2011-53057

Topics: Biological tissues , Calories

Both Hypoglycemia and Hyperglycemia Prevent Endothelial Cell Actin Fiber Alignment to Fluid Shear Stress

Steven F. Kemeny, Alisa Morss Clyne

SBC 2011; 345-346doi:https://doi.org/10.1115/SBC2011-53062

Topics: Endothelial cells , Fibers , Fluids , Shear stress , Blood glucose , Diabetes , Glucose , Membranes , Oxygen , Permeability

What Forces Does Cell Traction Force Microscopy Measure?

Evan A. Zamir

SBC 2011; 347-348doi:https://doi.org/10.1115/SBC2011-53266

Topics: Microscopy , Traction , Cellular mechanics , Displacement , Inverse problems , Silicones

Magnetoelastic Materials as Novel Bioactive Coatings to Improve Integration of Percutaneous Implants

Hal Holmes, Eli Vlaisavljevich, Ee Lim Tan, Keat G. Ong, Rupak M. Rajachar

SBC 2011; 349-350doi:https://doi.org/10.1115/SBC2011-53308

Topics: Biological tissues , Biomedicine , Coatings , Failure , Risk

Effect of ST2, a Fragment of ADAMTS13, on Cleavage of Von Willebrand Factor

Jin-Yu Shao, Yingchen Ling, J. Evan Sadler, Elaine M. Majerus

SBC 2011; 351-352doi:https://doi.org/10.1115/SBC2011-53317

Topics: Adhesion , Damage , Diseases , Endothelial cells , Plasmas (Ionized gases) , Platelets , Thrombosis , Wounds

Compression Force Measurement During Cell Spreading Using a Modified Atomic Force Microscope

Paul Weafer, Maarten H. van Es, Suzanne P. Jarvis, Patrick J. McGarry

SBC 2011; 353-354doi:https://doi.org/10.1115/SBC2011-53741

Topics: Atomic force microscopy , Compression , Force measurement

Model Systems and the Pericellular Environment

A Method for Quantitative Analysis of the Kinematics of Fibroblast Migration in a Monolayer Wound Model

Gil Topman, Orna Sharabani-Yosef, Amit Gefen

SBC 2011; 355-356doi:https://doi.org/10.1115/SBC2011-53070

Topics: Assaying , Fibroblasts , Kinematics

Fibroblast Behavior on Tunable Gels With Decreasing Elasticity

Michelle L. Previtera, Kevin Trout, Uday Chippada, Rene Schloss, Noshir A. Langrana

SBC 2011; 357-358doi:https://doi.org/10.1115/SBC2011-53251

Topics: Elasticity , Fibroblasts , DNA , Stiffness

In-Vitro Model of the Microscale Alveolar Environment

Natalia Higuita-Castro, Cosmin Mihai, Derek J. Hansford, Samir N. Ghadiali

SBC 2011; 359-360doi:https://doi.org/10.1115/SBC2011-53648

Topics: Biology , Biomimetics , Chemistry , Electrospinning , Endothelial cells , Fibers , Geometry , Lithography , Lung , Microchannels

Non-Destructive Real-Time Imaging of Cell Seeded Tissue Engineered Scaffolds

Bryce M. Whited, Matthias C. Hofmann, Chris G. Rylander, Aaron S. Goldstein, Joseph W. Freeman, Mark Furth, Shay Soker, Ge Wang, Yong Xu, Marissa N. Rylander

SBC 2011; 361-362doi:https://doi.org/10.1115/SBC2011-53721

Topics: Biological tissues , Imaging , Design , Assaying , Biocompatibility , Diseases , DNA , Mechanical properties , Stem cells , Tissue engineering

Changes in Biomechanical Environment of Cardiac Cells in Chick Embryos After Cardiac Outflow Tract Banding

Aiping Liu, Kent Thornburg, Ruikang Wang, Sandra Rugonyi

SBC 2011; 363-364doi:https://doi.org/10.1115/SBC2011-53732

Topics: Biomechanics , Outflow , Shear stress , Signals

The Mechanical and Biochemical Environment Controls Cellular Differentiation During Muscle Regeneration

Sarah Calve, Hans-Georg Simon

SBC 2011; 365-366doi:https://doi.org/10.1115/SBC2011-53767

Topics: Muscle , Biological tissues , Reservoirs , Stem cells , Testing

Multiscale Modeling in Biotransport

A Hybrid Particle-Cell Model for Nanoparticle Targeted Delivery in Microcirculation

Yaling Liu, Jifu Tan, Antony Thomas

SBC 2011; 367-368doi:https://doi.org/10.1115/SBC2011-53033

Topics: Nanoparticles , Particulate matter , Blood , Adhesion , Blood flow , Dynamics (Mechanics) , Fluids , Biomedicine , Collisions (Physics) , Deformation

Voxelized 3D Computational Transport Model of Infusions Into the Ventral Hippocampus: Comparison With Experimental Studies

Jung Hwan Kim, Garrett Astary, Svetlana Kantorovich, Thomas H. Mareci, Paul R. Carney, Malisa Sarntinoranont

SBC 2011; 369-370doi:https://doi.org/10.1115/SBC2011-53444

Topics: Biological tissues , Blood , Brain , Convection , Diffusion (Physics) , Diseases , Drugs , Imaging , Magnetic resonance , Modeling

Modelling of Magnetic Targeting of Therapeutic Nanoparticles in a Two Phase Microvessel Flow

Tobias Ecker, Christopher G. Rylander

SBC 2011; 371-372doi:https://doi.org/10.1115/SBC2011-53834

Topics: Anticancer drugs , Biological tissues , Blood vessels , Flow (Dynamics) , Magnetic particles , Magnets , Membranes , Modeling , Nanoparticles

Parametric Investigation of Magnetic Particle Transport for Targeted Drug Delivery Applications

Daniel B. Cooper, Pavlos P. Vlachos

SBC 2011; 373-374doi:https://doi.org/10.1115/SBC2011-53889

Topics: Drug delivery systems , Magnetic particles , Drugs , Cardiology , Magnetic fields , Particulate matter

Assessment of the Outflow Path Resistance of the Aqueous Humor Flow in the Eye

Sumanta Acharya, Jyoti Kathawate

SBC 2011; 375-376doi:https://doi.org/10.1115/SBC2011-53976

Topics: Flow (Dynamics) , Outflow , Pressure drop

Computational Models and Digital Image Analysis of Carbon Nanotube Mediated Laser Cancer Therapy

Jon Whitney, Saugata Sarkar, Xuanfeng Ding, Ravi Singh, Andrew Burke, Suzy Torti, Marissa Nichole Rylander

SBC 2011; 377-378doi:https://doi.org/10.1115/SBC2011-53984

Topics: Cancer , Carbon nanotubes , Lasers , Patient treatment , Biological tissues , Nanoparticles , Temperature , Phantoms , Kidney , Multi-walled nanotubes

Musculoskeletal Design and Devices

Comparison of Interface Stresses and Strains for Onlay and Inlay Unicompartmental Tibial Components

Peter S. Walker, Dhiraj S. Parakh, Miriam E. Chaudhary, Chih-Shing Wei

SBC 2011; 379-380doi:https://doi.org/10.1115/SBC2011-53199

Topics: Stress , Bone , Design , Metals

Automated Virtual Placement and Evaluation of Tibial Components for Knee Arthroplasty

Yifei Dai, Mary S. S. Wentorf, Jeffrey E. Bischoff

SBC 2011; 381-382doi:https://doi.org/10.1115/SBC2011-53244

Topics: Arthroplasty , Knee , Bone , Damage , Design , Geometry , Kinematics , Metals , Shapes , Soft tissues

Numerical Reduction of Position Error in a Mechanical Tracking Linkage for Arthroscopic Hip Surgery

Emily Geist, Kenji Shimada

SBC 2011; 383-384doi:https://doi.org/10.1115/SBC2011-53405

Topics: Arthroscopy , Errors , Linkages , Surgery , Anatomy , Biomedicine , Computer-aided engineering , Surgical tools

Design From Nature: Kinematic Modeling of the Seahorse Tail

Tomas Praet, Dominique Adriaens, Thibaut Rommens, Bert Masschaele, Sofie Van Cauter, Matthieu De Beule, Benedict Verhegghe

SBC 2011; 385-386doi:https://doi.org/10.1115/SBC2011-53408

Topics: Design , Kinematics , Modeling , Cycles , Engineers

Validation of an MRI-Based Method to Measure Tibiofemoral Joint Cartilage Contact Area

Jerome Allen, Venkata Gade, Peter J. Barrance

SBC 2011; 387-388doi:https://doi.org/10.1115/SBC2011-53881

Topics: Cartilage , Diseases , Health systems , Magnetic resonance imaging , Osteoarthritis

Evaluation of Regression Equations for Medial and Lateral Contact Force From Instrumented Knee Implant Data

Andrew J. Meyer, Darryl D. D’Lima, Scott A. Banks, James Coburn, Melinda Harman, Yoshinori Mikashima, Benjamin J. Fregly

SBC 2011; 389-390doi:https://doi.org/10.1115/SBC2011-53938

Topics: Knee joint prostheses , Knee , Stress , Design , Durability , Osteoarthritis

Musculoskeletal Tissue Engineering

Mechanical Stimulation Provides the Key Induction Signal for Tenogenic Differentiation of Human Mesenchymal Stem Cells in Braided Nanofibrous Scaffolds

Andrew M. Handorf, John G. Barber, Tyler J. Allee, Ray Vanderby, Wan-Ju Li

SBC 2011; 391-392doi:https://doi.org/10.1115/SBC2011-53130

Topics: Economics , Electromagnetic induction , Health systems , Orthopedics , Signals , Stem cells , Tendons , Wounds

Dynamic Culture Improves Mechanical Functionality of MSC-Laden Tissue Engineered Constructs in a Depth-Dependent Manner

Megan J. Farrell, Eric S. Comeau, Robert L. Mauck

SBC 2011; 393-394doi:https://doi.org/10.1115/SBC2011-53442

Topics: Biological tissues , Cartilage , Chondrocytes , Equilibrium (Physics) , Hydrogels , Mechanical properties , Stem cells , Tissue engineering

Muscle Injury Attenuates BMP-2 Mediated Tissue Regeneration in a Novel Rat Model of Composite Bone and Muscle Injury

Nick J. Willett, M. Alice Li, Brent A. Uhrig, Gordon L. Warren, Robert E. Guldberg

SBC 2011; 395-396doi:https://doi.org/10.1115/SBC2011-53589

Topics: Biological tissues , Bone , Composite materials , Muscle , Wounds , Soft tissues , Musculoskeletal system , Biomechanics , Diseases , Maintenance

Characterization of αGal(−) ECM Bioscaffolds: An Indication for Application in Tissue Engineering

Rui Liang, Matthew B. Fisher, Guoguang Yang, Christine Hall, Savio L-Y. Woo

SBC 2011; 397-398doi:https://doi.org/10.1115/SBC2011-53601

Topics: Biomechanics , Tendons , Tissue engineering , Urinary bladder

The Effect of Cyclic Hydrostatic Pressure on the Functional Development of Cartilaginous Tissues Engineered Using Bone Marrow Derived Mesenchymal Stem Cells

Eric G. Meyer, Conor T. Buckley, Daniel J. Kelly

SBC 2011; 399-400doi:https://doi.org/10.1115/SBC2011-53634

Topics: Biological tissues , Bone , Hydrostatic pressure , Stem cells , Cartilage , Chondrocytes , Mechanical properties , Maintenance , Orthopedics , Tissue engineering

Effects of Passaging on the Migration Response of Synovium-Derived Stem Cells to an Applied DC Electric Field

Andrea R. Tan, Elena Alegre-Aguarón, Divya N. Dujari, Sonal R. Sampat, J. Chloë Bulinski, Gerard A. Ateshian, Clark T. Hung

SBC 2011; 401-402doi:https://doi.org/10.1115/SBC2011-53674

Topics: Electric fields , Stem cells , Chondrocytes , Cartilage , Biological tissues , Bone , Maintenance , Membranes , Poles (Building) , Tissue engineering

Nano, Micro and Multiscale Mechanics I

In Silico Molecular Modeling of Collagen Crosslink Loading

Jonathan W. Bourne, Peter A. Torzilli

SBC 2011; 403-404doi:https://doi.org/10.1115/SBC2011-53352

Topics: Biological tissues , Blood vessels , Cartilage , Compression , Enzymes , Modeling , Proteins , Tendons , Tension

Multi-Scale Modeling of Cancer Cell Migration and Adhesion During Epithelial-to-Mesenchymal Transition

Rachel Zielinski, Cosmin Mihai, Samir Ghadiali

SBC 2011; 405-406doi:https://doi.org/10.1115/SBC2011-53511

Topics: Adhesion , Cancer , Multiscale modeling , Tumors , Biological tissues , Biomechanics , Cellular mechanics , Diseases , Stiffness , Traction

Flexural Rigidity of Intact Chlamydomonas Flagella Measured With an Optical Trap

R. J. Okamoto, J. Ying, B. L. Lewis, E. C. Ranz, J.-Y. Shao, S. K. Dutcher, P. V. Bayly

SBC 2011; 407-408doi:https://doi.org/10.1115/SBC2011-53615

Topics: Fluids , Stiffness

A Combined In Vitro and In Silico Approach to Estimate the Molecular Arrangement Within a Fibronectin Fiber

Mark J. Bradshaw, Michael L. Smith

SBC 2011; 409-410doi:https://doi.org/10.1115/SBC2011-53809

Topics: Fibers , Adhesion , Feedback , Proteins , Spectroscopy

Influence of Zona Pellucida Area Expansion Stiffness on the Passive Response of Oocytes to Osmotic Loading

Sevan R. Oungoulian, Kelvin Chan, Jason Barritt, Casey A. McDonald, Alan B. Copperman, David Elad, Gerard A. Ateshian

SBC 2011; 411-412doi:https://doi.org/10.1115/SBC2011-53826

Topics: Cycles , Elasticity , Fertilizer application , Hardening , Shear (Mechanics) , Shells , Stiffness

On the Mechanics of Microtubule Filaments

Mehrdad Mehrbod, Mohammad R. K. Mofrad

SBC 2011; 413-414doi:https://doi.org/10.1115/SBC2011-53896

Topics: Bearings , Buckling , Cables , Cellular mechanics , Compression , Continuum mechanics , Flexural behavior , Hinges , Imaging , Modeling

Nano, Micro and Multiscale Mechanics II

A Nanoindentation Method for Hydrated Compliant Materials

Donna M. Ebenstein

SBC 2011; 415-416doi:https://doi.org/10.1115/SBC2011-53095

Topics: Nanoindentation , Biomaterials , Adhesion , Biological tissues , Errors