This paper presents preliminary experimental results on the influence of the flow approach angle on the acoustic resonance excitation of in-line tube bundles in cross-flow. The pitch-to-diameter ratio (P/D) of the in-line tube bundles investigated is P/D = 1.733. The flow approach angle was investigated by physically rotating the tube bundle clockwise relative to the flow direction. The tube bundles are capable of rotating with increments of 5° up to an angle of 45°. For brevity, only the results for the 0° and 30° orientation will be presented herein. For the 0° orientation, two Strouhal frequencies (St1 = 0.437 and St2 = 0.252) were observed. However, only one of these frequencies (St1 = 0.437) was capable of exciting resonance. During resonance, a peak sound pressure level (SPL) of 170 dB was achieved. The Strouhal frequencies and peak SPL agrees well with what has been presented in the literature. For the 30° orientation, only one Strouhal frequency (St1 = 0.98) was measured. At this orientation, the lock-in phenomenon occurred at a much lower flow velocity compared to the 0° orientation with a peak SPL reaching 153 dB. Jumps in the lock-in frequency were observed at the 30° orientation. This phenomenon is associated with two reasons. The first reason is a partial lock-in with an acoustic resonant mode, due to the acoustic energy not being fully trapped within the tube bundle. The second reason is related to the changes in the apparent speed of sound resulting in variations in the acoustic cross-mode frequency depending on where the excitation source is emanating from within the tube bundle. A brief summary of the results is presented in this paper.