Purpose: Encapsulation of contrast agent within a nanoporous matrix has been shown to enhance contrast performance. Previous investigators have shown an up to 40-fold increase in T1 image contrast enhancement of gadolinium with encapsulation in carbon nanotubes. In this study we examined silicon encapsulation as a means of contrast enhancement in superparamagnetic iron oxide nanoparticles (SPIONs) using a particle-agarose phantom. Methods: 1μm discoidal pSi particles were loaded with 30 nm SPIONs through capillary action. Loaded particle preparations along with free SPION controls were homogeneously distributed within an agarose substrate and imaged using a 7-tesla small-bore MRI. ICP-AES was used to determine the concentration of free elemental iron in sample preparations. Results: Silicon encapsulation of 30nm SPIONs did not result in a clinically significant enhancement of negative contrast (T2 and T2*) in MRI. However, it is unclear the extent to which limited diffusion of water protons, both through silicon encapsulation and the use of an agarose substrate, counteracts the theoretical increase in relaxivity due to aggregation.
Skip Nav Destination
ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology
February 4–6, 2013
Boston, Massachusetts, USA
Conference Sponsors:
- Nanotechnology Institute
- Bioengineering Division
ISBN:
978-0-7918-4533-2
PROCEEDINGS PAPER
Porous Silicon-Superparamagnetic Iron Oxide Complexes and Impact on Negative Contrast Enhancement in MRI
Charles M. Lundquist,
Charles M. Lundquist
The University of Texas Medical School at Houston, Houston, TX
Search for other works by this author on:
Christopher H. Loo,
Christopher H. Loo
The Methodist Hospital Research Institute, Houston, TX
Search for other works by this author on:
Aaron Mack,
Aaron Mack
The Methodist Hospital Research Institute, Houston, TX
Search for other works by this author on:
Jianhua Gu,
Jianhua Gu
The Methodist Hospital Research Institute, Houston, TX
Search for other works by this author on:
Jim A. Bankson,
Jim A. Bankson
MD Anderson Cancer Center, Houston, TX
Search for other works by this author on:
Rita E. Serda
Rita E. Serda
The Methodist Hospital Research Institute, Houston, TX
Search for other works by this author on:
Charles M. Lundquist
The University of Texas Medical School at Houston, Houston, TX
Christopher H. Loo
The Methodist Hospital Research Institute, Houston, TX
Aaron Mack
The Methodist Hospital Research Institute, Houston, TX
Jianhua Gu
The Methodist Hospital Research Institute, Houston, TX
Jim A. Bankson
MD Anderson Cancer Center, Houston, TX
Rita E. Serda
The Methodist Hospital Research Institute, Houston, TX
Paper No:
NEMB2013-93065, V001T01A001; 3 pages
Published Online:
November 4, 2013
Citation
Lundquist, CM, Loo, CH, Mack, A, Gu, J, Bankson, JA, & Serda, RE. "Porous Silicon-Superparamagnetic Iron Oxide Complexes and Impact on Negative Contrast Enhancement in MRI." Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. Boston, Massachusetts, USA. February 4–6, 2013. V001T01A001. ASME. https://doi.org/10.1115/NEMB2013-93065
Download citation file:
6
Views
Related Proceedings Papers
Related Articles
Incorporation, Release, and Effectiveness of Dexamethasone in Poly(Lactic-Co-Glycolic Acid) Nanoparticles for Inner Ear Drug Delivery
J. Nanotechnol. Eng. Med (February,2011)
Magnetic Assisted Transport of PLGA Nanoparticles Through a Human Round Window Membrane Model
J. Nanotechnol. Eng. Med (August,2010)
CT Visualization of Cryoablation in Pulmonary Veins
J. Med. Devices (June,2009)
Related Chapters
Materials and Methods of Synthesis
Silver Nanoparticles: Properties, Synthesis Techniques, Characterizations, Antibacterial and Anticancer Studies
Conclusion
Silver Nanoparticles: Properties, Synthesis Techniques, Characterizations, Antibacterial and Anticancer Studies
Simple Routes to Synthesize Carbon Nanotubes and Its Decoration by Palladium Nanoparticles
International Conference on Advanced Computer Theory and Engineering, 4th (ICACTE 2011)