Microcantilever-based biosensors are rapidly becoming an enabling sensing technology for a variety of label-free biological applications due to their wide applicability, versatility and low cost. It is thus imperative for us to reveal the physical origin of adsorption-induced deformation, and to further analyze its implication of microscopic mechanisms on macroscopic deformation. In the paper, we study adsorption-induced surface stresses and microcantilever motion in alkanethiolate SAMs on Au surface. We develop a multiscale method that can analyze deformation of micro-cantilever beam subjected to bio-adsorption mechanisms calculated by ab-initio simulation and classical molecular dynamics. The adsorption mechanisms of different SAMs adsorbed on Au(111) surface, in the dry and liquid phase, are studied by ab-initio simulation and the adsorption-induced stresses are calculated through the multiscale method. The results give insight into the atomic forces and positions that play a key role in producing adsorption-induced surface stresses and resultant mechanical bending of microcantilevers.
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ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
February 7–10, 2010
Houston, Texas, USA
Conference Sponsors:
- ASME Nanotechnology Council
ISBN:
978-0-7918-4392-5
PROCEEDINGS PAPER
Alkanethiol Self-Assembled Monolayers on Microcantilever Biosensor
Chia-Ching Chou,
Chia-Ching Chou
National Taiwan University, Taipei, Taiwan
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Shu-Wei Chang,
Shu-Wei Chang
National Taiwan University, Taipei, Taiwan
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Chuin-Shan Chen
Chuin-Shan Chen
National Taiwan University, Taipei, Taiwan
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Chia-Ching Chou
National Taiwan University, Taipei, Taiwan
Shu-Wei Chang
National Taiwan University, Taipei, Taiwan
Chuin-Shan Chen
National Taiwan University, Taipei, Taiwan
Paper No:
NEMB2010-13214, pp. 41-42; 2 pages
Published Online:
December 22, 2010
Citation
Chou, C, Chang, S, & Chen, C. "Alkanethiol Self-Assembled Monolayers on Microcantilever Biosensor." Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. Houston, Texas, USA. February 7–10, 2010. pp. 41-42. ASME. https://doi.org/10.1115/NEMB2010-13214
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