The current large demands for transplant organs and tissues has led to extensive research on material synthesis and fabrication methods for biodegradable polymeric scaffolds, which are required to have high porosity, well interconnected pore structure, and good mechanical properties. However, the majority of current scaffold fabrication techniques are either for batch processes or use organic solvents, which can be detrimental to cell survival and tissue growth. The ability to mass produce solvent-free, highly porous, highly interconnected scaffolds with complex geometries is essential to provide off-the-shelf availability [1]. Injection molding has long been used for mass production of complex 3D plastic parts. The low-cost manufacturing, repeatability, and design flexibility inherent in the injection molding process make it an ideal manufacturing process to create 3D scaffolds, as long as high porosity and interconnectivity can be imparted into the finished product.
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ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology
February 7–10, 2010
Houston, Texas, USA
Conference Sponsors:
- ASME Nanotechnology Council
ISBN:
978-0-7918-4392-5
PROCEEDINGS PAPER
The Effect of Nano Hydroxyapatite Particles on Morphology and Mechanical Properties of Microcellular Injection Molded Polylactide/Hydroxyapatite Tissue Scaffold
Adam Kramschuster,
Adam Kramschuster
University of Wisconsin-Stout, Menomonie, WI
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Lih-Sheng Turng,
Lih-Sheng Turng
University of Wisconsin-Madison, Madison, WI
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Wan-Ju Li,
Wan-Ju Li
University of Wisconsin-Madison, Madison, WI
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Yiyan Peng,
Yiyan Peng
University of Wisconsin-Madison, Madison, WI
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Jun Peng
Jun Peng
South China University of Technology, Guangzhou, China
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Adam Kramschuster
University of Wisconsin-Stout, Menomonie, WI
Lih-Sheng Turng
University of Wisconsin-Madison, Madison, WI
Wan-Ju Li
University of Wisconsin-Madison, Madison, WI
Yiyan Peng
University of Wisconsin-Madison, Madison, WI
Jun Peng
South China University of Technology, Guangzhou, China
Paper No:
NEMB2010-13290, pp. 175-178; 4 pages
Published Online:
December 22, 2010
Citation
Kramschuster, A, Turng, L, Li, W, Peng, Y, & Peng, J. "The Effect of Nano Hydroxyapatite Particles on Morphology and Mechanical Properties of Microcellular Injection Molded Polylactide/Hydroxyapatite Tissue Scaffold." Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. Houston, Texas, USA. February 7–10, 2010. pp. 175-178. ASME. https://doi.org/10.1115/NEMB2010-13290
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