This paper presents the design of a MEMS-based active DEP (dielectrophoresis) cell filtration microchip for manipulating and separating biological cells. Depending on the dielectric constant and polarizability, biological cells are either attracted to or repelled from the electrodes inside a microfluidic channel. Through the optimization of electrode geometries using the finite element method (FEM), it was found that circular electrodes are capable of producing a more uniform and larger gradient of the squared electric field intensity compared to electrodes of other shapes, such as square, diamond, or triangle, FEM numerical simulation results were also used to determine 50μm as the optimal circular electrode diameter and 25μm as the optimal gap between electrodes.
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ASME 4th Integrated Nanosystems Conference
September 12–14, 2005
Berkeley, California, USA
Conference Sponsors:
- Nanotechnology Institute
ISBN:
0-7918-4208-8
PROCEEDINGS PAPER
Microelectrode Design in MEMS-Based DEP Cell Filtration Devices
Mohammed J. Ahamed,
Mohammed J. Ahamed
University of Toronto, Toronto, ON, Canada
Search for other works by this author on:
Mohammad A. Rahman
Mohammad A. Rahman
University of Toronto, Toronto, ON, Canada
Search for other works by this author on:
Mohammed J. Ahamed
University of Toronto, Toronto, ON, Canada
Mohammad A. Rahman
University of Toronto, Toronto, ON, Canada
Paper No:
NANO2005-87049, pp. 7-8; 2 pages
Published Online:
October 15, 2008
Citation
Ahamed, MJ, & Rahman, MA. "Microelectrode Design in MEMS-Based DEP Cell Filtration Devices." Proceedings of the ASME 4th Integrated Nanosystems Conference. Design, Synthesis, and Applications. Berkeley, California, USA. September 12–14, 2005. pp. 7-8. ASME. https://doi.org/10.1115/NANO2005-87049
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