This paper presents the fabrication and testing of electric cell-substrate impedance spectroscopy (ECIS) electrodes on a stretchable membrane. This is the first time when ECIS electrodes were fabricated on a stretchable substrate and ECIS measurements on mammalian cells exposed to cyclic strain of 10% were successfully demonstrated. A chemical was used to form strong chemical bond between gold electrodes of ECIS sensor and polymer membrane, which enable the electrodes keep good conductive ability during cyclic stretch. The stretchable membrane integrated with the ECIS sensor can simulate and replicate the dynamic environment of organism and enable the analysis of the cells activity involved in cells attachment and proliferation in vitro. Bovine aortic endothelial cells (BAEC) were used to evaluate the endothelial function influenced by mechanical stimuli in this research because they undergo in vivo cyclic physiologic elongation produced by the blood circulation in the arteries.
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ASME 2016 International Mechanical Engineering Congress and Exposition
November 11–17, 2016
Phoenix, Arizona, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-5064-0
PROCEEDINGS PAPER
STRETCHABLE Lab-on-Chip Device With Impedance Spectroscopy Capability for Mammalian Cell Studies
Xudong Zhang,
Xudong Zhang
City College of New York, New York, NY
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Anis Nurashikin Nordin,
Anis Nurashikin Nordin
International Islamic University, Gombak, Malaysia
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Fang Li,
Fang Li
New York Institute of Technology, New York, NY
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Ioana Voiculescu
Ioana Voiculescu
City College of New York, New York, NY
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Xudong Zhang
City College of New York, New York, NY
Anis Nurashikin Nordin
International Islamic University, Gombak, Malaysia
Fang Li
New York Institute of Technology, New York, NY
Ioana Voiculescu
City College of New York, New York, NY
Paper No:
IMECE2016-66156, V010T13A005; 3 pages
Published Online:
February 8, 2017
Citation
Zhang, X, Nordin, AN, Li, F, & Voiculescu, I. "STRETCHABLE Lab-on-Chip Device With Impedance Spectroscopy Capability for Mammalian Cell Studies." Proceedings of the ASME 2016 International Mechanical Engineering Congress and Exposition. Volume 10: Micro- and Nano-Systems Engineering and Packaging. Phoenix, Arizona, USA. November 11–17, 2016. V010T13A005. ASME. https://doi.org/10.1115/IMECE2016-66156
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