Recently, magnetic targeted drug delivery has been focused on the efficiency of magnetic nanoparticles (MNP) encapsulated in polymeric materials and drug molecules. The MNP can be introduced into the blood stream intravenously and be guided to the target site by the use of a magnetic field. The ability of the therapeutic agents to access the target site effectively depends on physicochemical properties of the drug loaded MNP, field strength and geometry, depth of the target tissue, rate of blood flow and vascular supply. A computational fluid dynamics (CFD) approach is utilized in this study to understand the fluid flow mechanism of MNP introduced in the blood vessel in the presence of a magnetic field. The effect of magnetic capture on the flow characteristics of the blood was investigated. CFD technique may offer insight into the mechanism of time-varying fluid flow in human arteries. This knowledge can be harnessed to improve magnetic capture and drug efficiency. The focus of this study is on how the size of the blood vessels, the strength of the magnetic field, and the velocity of the fluid within the vessels affect the delivery of the therapeutic agents. The results would be useful for the biomedical and pharmaceutical industries.
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ASME 2011 International Mechanical Engineering Congress and Exposition
November 11–17, 2011
Denver, Colorado, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-5488-4
PROCEEDINGS PAPER
CFD Analysis of Drug Carrying Magnetic Nanocomposite Carriers Under Magnetic Fields
H. L. Wamocha,
H. L. Wamocha
Wichita State University, Wichita, KS
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R. Tandel,
R. Tandel
Wichita State University, Wichita, KS
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H. Lankarani,
H. Lankarani
Wichita State University, Wichita, KS
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R. Asmatulu
R. Asmatulu
Wichita State University, Wichita, KS
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H. L. Wamocha
Wichita State University, Wichita, KS
R. Tandel
Wichita State University, Wichita, KS
H. Lankarani
Wichita State University, Wichita, KS
R. Asmatulu
Wichita State University, Wichita, KS
Paper No:
IMECE2011-62713, pp. 861-870; 10 pages
Published Online:
August 1, 2012
Citation
Wamocha, HL, Tandel, R, Lankarani, H, & Asmatulu, R. "CFD Analysis of Drug Carrying Magnetic Nanocomposite Carriers Under Magnetic Fields." Proceedings of the ASME 2011 International Mechanical Engineering Congress and Exposition. Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology. Denver, Colorado, USA. November 11–17, 2011. pp. 861-870. ASME. https://doi.org/10.1115/IMECE2011-62713
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