Combined Effect of Isoproterenol and Mechanical Oscillation on the Contractile Response of Mice Airway Smooth Muscle

An asthmatic attack is instigated by hyperconstriction of airway smooth muscle (ASM). This can be relieved with bronchodilator medication such as Isoproterenol (ISO). This paper hypothesizes that mechanical oscillations may improve drugs therapy when combined with ISO. Preliminary results indicate that combining ISO with breathing equivalent mechanical oscillations trends to increase the relaxation response as compared with the use of ISO alone. The effect of superposed oscillations in the range of 10–30 Hz of frequency applied over breathing equivalent mechanical oscillations was also assessed in the study.