The behavior of molecules confined within nanochannels may provide new insight into important chemical and biological mechanisms. As such, the ability to measure the diffusion coefficient of molecules accurately and rapidly is critical. Toward this end, we demonstrate a new method for measuring the diffusion coefficient of analytes in nanoscale environments. Based on nanoscale electrokinetic transport theory, a numerical simulation was developed to determine the spatial concentration of analyte within a nanofluidic T-shaped channel for a given Peclet number. The resulting concentration profiles were compared to experimental data to determine the Peclet number that gives the minimum least-square error. Using this approach, the diffusion coefficient of sodium fluorescein was measured and found to be within the error of previously published values. This method is envisioned to be a novel analytical tool to rapidly and accurately measure diffusion coefficients of small analytes, and to measure the effective diffusion coefficients of more complex species such as DNA and peptides when confined within a nanochannel.
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ASME 2007 International Mechanical Engineering Congress and Exposition
November 11–15, 2007
Seattle, Washington, USA
Conference Sponsors:
- ASME
ISBN:
0-7918-4305-X
PROCEEDINGS PAPER
The Measurement of Diffusion Coefficient Using Nanofluidic Channels
David Huber,
David Huber
Sandia National Laboratories, Livermore, CA
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Marci Markel,
Marci Markel
Sandia National Laboratories, Livermore, CA
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G. Tayhas R. Palmore,
G. Tayhas R. Palmore
Brown University, Providence, RI
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Sumita Pennathur
Sumita Pennathur
University of California at Santa Barbara, Santa Barbara, CA
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Steve Rhieu
Brown University, Providence, RI
David Huber
Sandia National Laboratories, Livermore, CA
Marci Markel
Sandia National Laboratories, Livermore, CA
G. Tayhas R. Palmore
Brown University, Providence, RI
Sumita Pennathur
University of California at Santa Barbara, Santa Barbara, CA
Paper No:
IMECE2007-42562, pp. 957-962; 6 pages
Published Online:
May 22, 2009
Citation
Rhieu, S, Huber, D, Markel, M, Palmore, GTR, & Pennathur, S. "The Measurement of Diffusion Coefficient Using Nanofluidic Channels." Proceedings of the ASME 2007 International Mechanical Engineering Congress and Exposition. Volume 11: Micro and Nano Systems, Parts A and B. Seattle, Washington, USA. November 11–15, 2007. pp. 957-962. ASME. https://doi.org/10.1115/IMECE2007-42562
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