Numerical simulation results are obtained for isotachophoresis (ITP) in two-dimensional straight michrochannel. This 2D ITP model is formulated based on finite volume schemes using 5 ionic components: one leader (LE), one terminator (TE), two samples (Sample A and B), and a counter ion electrolyte (C). Distinct net mobilities and diffusion coefficients are assigned to all ionic components, and an electric field is maintained along the channel to carry out the electrophoretic separation in microchannel. The computer model is developed to solve mass and charge conservation equations and to satisfy electro-neutrality condition in the system. Three different finite volume schemes, e.g. power-law, hybrid and upwind, are tested to obtain the best numerical solution of this electrophoretic problem. Numerical results show that power law scheme performs better; grid Peclet number up to 20 is acceptable for this nonlinear isotachophoresis. The effects of applied electric potential, ionic mobilities and initial distribution of samples on the separation behavior are also presented.
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ASME 2007 International Mechanical Engineering Congress and Exposition
November 11–15, 2007
Seattle, Washington, USA
Conference Sponsors:
- ASME
ISBN:
0-7918-4305-X
PROCEEDINGS PAPER
Modeling and Simulation of Isotachophoresis for Chemical Separation of Charged Species
Jaesool Shim,
Jaesool Shim
Washington State University, Pullman, WA
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Prashanta Dutta,
Prashanta Dutta
Washington State University, Pullman, WA
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Cornelius F. Ivory
Cornelius F. Ivory
Washington State University, Pullman, WA
Search for other works by this author on:
Jaesool Shim
Washington State University, Pullman, WA
Prashanta Dutta
Washington State University, Pullman, WA
Cornelius F. Ivory
Washington State University, Pullman, WA
Paper No:
IMECE2007-41334, pp. 13-20; 8 pages
Published Online:
May 22, 2009
Citation
Shim, J, Dutta, P, & Ivory, CF. "Modeling and Simulation of Isotachophoresis for Chemical Separation of Charged Species." Proceedings of the ASME 2007 International Mechanical Engineering Congress and Exposition. Volume 11: Micro and Nano Systems, Parts A and B. Seattle, Washington, USA. November 11–15, 2007. pp. 13-20. ASME. https://doi.org/10.1115/IMECE2007-41334
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