Hydrogels have numerous applications in biomedical engineering and biotechnology, such as in cellular and tissue engineering. The transient mechanical behavior of hydrogels is related to its interstitial fluid flow which is governed by hydraulic permeability. The hydraulic permeability of hydrogels and other hydrated soft tissues (e.g., cartilage and intervertebral disc) is deformation dependent [1–3]. Several empirical expressions for deformation-dependent permeability of cartilage have been proposed, in order to quantify the fluid flow within a gel or tissue under mechanical loading [1,2,4]. In this paper, we report a new approach to investigating deformation-dependent permeability of hydrogels. The objective of this study is to find a relationship between hydraulic permeability and tissue porosity (water content) for hydrogels, and in turn derive its deformation-dependent permeability. This study is important for understanding biological responses of cells to interstitial fluid flow in gels or in cartilage under mechanical loading.
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ASME 2002 International Mechanical Engineering Congress and Exposition
November 17–22, 2002
New Orleans, Louisiana, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-3650-9
PROCEEDINGS PAPER
New Insight Into Deformation-Dependent Hydraulic Permeability of Hydrogels and Cartilage
Weiyong Gu
Weiyong Gu
University of Miami, Coral Gables, FL
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Hai Yao
University of Miami, Coral Gables, FL
Weiyong Gu
University of Miami, Coral Gables, FL
Paper No:
IMECE2002-32520, pp. 133-134; 2 pages
Published Online:
June 3, 2008
Citation
Yao, H, & Gu, W. "New Insight Into Deformation-Dependent Hydraulic Permeability of Hydrogels and Cartilage." Proceedings of the ASME 2002 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering. New Orleans, Louisiana, USA. November 17–22, 2002. pp. 133-134. ASME. https://doi.org/10.1115/IMECE2002-32520
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