Abstract

We measured directly the partial pressure of oxygen (pO2) in new fibrosarcoma (NFSa) tumors grown in C3H/He mice using microcoaxial O2 electrodes in vivo. The pO2 in tumors was monitored after a single dose of X-ray or carbon-12 irradiation. After irradiation, tumor volume temporally shrinked, and pO2 simultaneously increased. Carbon-12 irradiation reoxygenated tumors between the 1st and 9th day after the irradiation, while x-ray irradiation reoxygenated tumors between the 3rd and 8th day. We found that reoxygenation period after carbon-12 irradiation started earlier and continued longer than X-ray irradiation.

Volume Subject Area:
Poster Session
Topics:
Biological tissues, Carbon, Irradiation (Radiation exposure), Tumors, X-rays, Electrodes, Oxygen, Pressure
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Copyright © 1998 by The American Society of Mechanical Engineers
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