It is well known that vortex shedding can cause vibration of cylindrical structures. However, an actual case of vortex shedding from a chemical plant distillation column revealed that pipework on the outside of the column can cause the vibration to be significantly enhanced in comparison to that of a bare cylinder. This observation contradicts the commonly held view that equipment and pipework on the outside of cylinders reduces the effects of vortex shedding. Wind tunnel studies on a fully flexible sectional model of the column indicated that in some cases relatively small pipework can increase the vibration by a factor of three in comparison to the vibration of a plain cylinder. The case history, the wind tunnel studies and the solution adopted for the column are described in this paper.