Animal skeletal muscle exhibits very interesting behavior at near-stall forces (when the muscle is loaded so strongly that it can barely contract). Near this physical limit, the actinmyosin cross bridges do more work than their energy releasing molecules, Adenosine TriPhosphate (ATP) suggest they can. It has been shown that the advantageous utilization of thermal agitation is a likely source for this increased capacity. Here, we propose a spatially two-dimensional mechanical model to illustrate how thermal agitation can be harvested for useful mechanical work in molecular machinery without rate functions or empirically-inspired spatial potential functions. Additionally, the model accommodates variable lattice spacing, and it paves the way for a full three dimensional model of cross-bridge interactions where myosin II may be azimuthally misaligned with actin binding sites. With potential energy sources based entirely on realizable components, this model lends itself to the design of artificial, molecular-scale motors.
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ASME 2018 International Mechanical Engineering Congress and Exposition
November 9–15, 2018
Pittsburgh, Pennsylvania, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-5202-6
PROCEEDINGS PAPER
A Dynamic Escape Problem of Molecular Motors
Dean Culver,
Dean Culver
US Army Research Laboratory, Aberdeen, MD
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Bryan Glaz,
Bryan Glaz
US Army Research Laboratory, Aberdeen, MD
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Samuel Stanton
Samuel Stanton
US Army Research Office, Durham, NC
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Dean Culver
US Army Research Laboratory, Aberdeen, MD
Bryan Glaz
US Army Research Laboratory, Aberdeen, MD
Samuel Stanton
US Army Research Office, Durham, NC
Paper No:
IMECE2018-88612, V003T04A081; 9 pages
Published Online:
January 15, 2019
Citation
Culver, D, Glaz, B, & Stanton, S. "A Dynamic Escape Problem of Molecular Motors." Proceedings of the ASME 2018 International Mechanical Engineering Congress and Exposition. Volume 3: Biomedical and Biotechnology Engineering. Pittsburgh, Pennsylvania, USA. November 9–15, 2018. V003T04A081. ASME. https://doi.org/10.1115/IMECE2018-88612
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