Heart valves are inhomogeneous microstructure with nonlinear anisotropic properties and constantly experience different stress states during cardiac cycles. However, how tissue-level mechanical forces can translate into altered cellular stress states remains unclear, and associated biomechanical regulation in the tissue has not been fully understood. In the current study, we use an image-based finite element method to investigate factors contributing the stress distributions at both tissue- and cell-levels inside the healthy heart valve tissues. Effects of tissue microstructure, inhomogeneity, and anisotropic material property at different diastole states are discussed to provide a better understanding of structure-mechanics-property interactions, which alters tissue-to-cell stress transfer mechanisms in heart valve tissue. To the best of the authors’ knowledge, this is the first study reporting on the evolution of stress fields at both the tissue- and cellular-levels in valvular tissue, and thus contributes toward refining our collective understanding of valvular tissue micromechanics while providing a computational tool enabling further study of valvular cell-tissue interactions.
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ASME 2013 International Mechanical Engineering Congress and Exposition
November 15–21, 2013
San Diego, California, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-5638-3
PROCEEDINGS PAPER
Tissue- and Cell-Level Stress Distributions of the Heart Valve Tissue During Diastole
Siyao Huang,
Siyao Huang
North Carolina State University, Raleigh, NC
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Hsiao-Ying Shadow Huang
Hsiao-Ying Shadow Huang
North Carolina State University, Raleigh, NC
Search for other works by this author on:
Siyao Huang
North Carolina State University, Raleigh, NC
Hsiao-Ying Shadow Huang
North Carolina State University, Raleigh, NC
Paper No:
IMECE2013-63229, V009T10A050; 5 pages
Published Online:
April 2, 2014
Citation
Huang, S, & Huang, HS. "Tissue- and Cell-Level Stress Distributions of the Heart Valve Tissue During Diastole." Proceedings of the ASME 2013 International Mechanical Engineering Congress and Exposition. Volume 9: Mechanics of Solids, Structures and Fluids. San Diego, California, USA. November 15–21, 2013. V009T10A050. ASME. https://doi.org/10.1115/IMECE2013-63229
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