The Chandler loop is an artificial circulatory platform for in vitro hemodynamic experiments. In most experiments, the working fluid is subjected to a stress field via rotation of the Chandler loop, which, in turn, induces biochemical responses of the suspended cells. For very low rotation rates, the stress field can be approximated using laminar flow in a straight tube as a model. However, as the rotation rate increases, while still maintaining laminar flow, the effect of the tube curvature causes the stress field to deviate considerably from the straight tube approximation. In this manuscript, we investigate the flow and associated strain rate field of an incompressible Newtonian fluid in a Chandler loop as a function of the governing non-dimensional fluid dynamic parameters. We find that the Dean number, which is proportional to the rotation rate, is the dominant parameter in determining the fluid strain rate. We propose an empirical formula for predicting the average fluid strain rate magnitude in the working fluid that is valid over a wide parameter space to be used in lieu of the common, yet restrictive, straight tube-based prediction.
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ASME 2013 International Mechanical Engineering Congress and Exposition
November 15–21, 2013
San Diego, California, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-5622-2
PROCEEDINGS PAPER
A Numerical Investigation of the Fluid Flow in a Chandler Loop for Thrombus Studies
Hisham Touma,
Hisham Touma
Polytechnic Institute of New York University, Brooklyn, NY
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Iskender Sahin,
Iskender Sahin
Polytechnic Institute of New York University, Brooklyn, NY
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Tidimogo Gaamangwe,
Tidimogo Gaamangwe
University of Waterloo, Waterloo, ON, Canada
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Maud B. Gorbet,
Maud B. Gorbet
University of Waterloo, Waterloo, ON, Canada
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Sean D. Peterson
Sean D. Peterson
University of Waterloo, Waterloo, ON, Canada
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Hisham Touma
Polytechnic Institute of New York University, Brooklyn, NY
Iskender Sahin
Polytechnic Institute of New York University, Brooklyn, NY
Tidimogo Gaamangwe
University of Waterloo, Waterloo, ON, Canada
Maud B. Gorbet
University of Waterloo, Waterloo, ON, Canada
Sean D. Peterson
University of Waterloo, Waterloo, ON, Canada
Paper No:
IMECE2013-63916, V03BT03A036; 10 pages
Published Online:
April 2, 2014
Citation
Touma, H, Sahin, I, Gaamangwe, T, Gorbet, MB, & Peterson, SD. "A Numerical Investigation of the Fluid Flow in a Chandler Loop for Thrombus Studies." Proceedings of the ASME 2013 International Mechanical Engineering Congress and Exposition. Volume 3B: Biomedical and Biotechnology Engineering. San Diego, California, USA. November 15–21, 2013. V03BT03A036. ASME. https://doi.org/10.1115/IMECE2013-63916
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