Many theories and mathematical simulations have been proposed concerning urine concentrating mechanism (UCM). The WKM and region approach are the two most valuable methods for compensating the effect of tubule’s architecture in renal medulla. They both have tried to simulate tubule’s confinement within a particular region mathematically in one spatial dimension. In this study, continuity, momentum and species transport equations along with standard expressions for transtubular solutes and water transports on tubule’s membrane were solved numerically in three spatial dimensions which practically is the main significance of our novel approach. Model structure has been chosen as simple as possible to minimize the effect of other factors in tubule’s solute and water exchange. It has been tried to simulate the preferential interaction between tubules by introducing different diffusion coefficients for solutes in the intermediate media in order that changing this physical parameter directly could influence tubule’s confinement with respect to each other. The results have been discussed in detail and then the effect of solute’s diffusivity on UCM has been investigated subsequently. In overall, it has been found out that this simulation can validate the integrity of our proposed approach for further investigation in this field.
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ASME 2013 International Mechanical Engineering Congress and Exposition
November 15–21, 2013
San Diego, California, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-5622-2
PROCEEDINGS PAPER
A Novel Approach for Compensating the Significance of Tubule’s Architecture in Urine Concentrating Mechanism of Renal Medulla
Salman Sohrabi,
Salman Sohrabi
Sharif University of Technology, Tehran, Iran
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Seyyed Mahdi Nemati Mehr,
Seyyed Mahdi Nemati Mehr
Sharif University of Technology, Tehran, Iran
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Pedram Falsafi
Pedram Falsafi
Sharif University of Technology, Tehran, Iran
Search for other works by this author on:
Salman Sohrabi
Sharif University of Technology, Tehran, Iran
Seyyed Mahdi Nemati Mehr
Sharif University of Technology, Tehran, Iran
Pedram Falsafi
Sharif University of Technology, Tehran, Iran
Paper No:
IMECE2013-63747, V03BT03A035; 8 pages
Published Online:
April 2, 2014
Citation
Sohrabi, S, Nemati Mehr, SM, & Falsafi, P. "A Novel Approach for Compensating the Significance of Tubule’s Architecture in Urine Concentrating Mechanism of Renal Medulla." Proceedings of the ASME 2013 International Mechanical Engineering Congress and Exposition. Volume 3B: Biomedical and Biotechnology Engineering. San Diego, California, USA. November 15–21, 2013. V03BT03A035. ASME. https://doi.org/10.1115/IMECE2013-63747
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