This paper integrates computational fluid dynamics (CFD) and radiotherapy data for accurate simulation of spatio-temporal flow and deformation in real human lung. Specifically, it utilizes a mathematical formulation that fuses the CFD predictions of lung displacement with the corresponding radiotherapy data using the theory of Tikhonov regularization. The lung is assumed to behave as a poro-elastic medium with heterogeneous Young’s modulus. The CFD scheme utilizes a flow-structure interaction model to simultaneously solve the airflow equations and structural dynamics of the lung tissue, with allowance for interaction at the interface. The simulation is performed on a 3D lung geometry reconstructed from 4D CT scan dataset of real human patients. The predicted deformation is fused with inverse estimation data by means of the fusion algorithm to obtain the optimal results.
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ASME 2012 International Mechanical Engineering Congress and Exposition
November 9–15, 2012
Houston, Texas, USA
Conference Sponsors:
- ASME
ISBN:
978-0-7918-4518-9
PROCEEDINGS PAPER
Application of Fusion Algorithm to Human Lung Dynamics
Behnaz Seyfi,
Behnaz Seyfi
University of Central Florida, Orlando, FL
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Anand P. Santhanam,
Anand P. Santhanam
University of California, Los Angeles, Los Angeles, CA
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Olusegun J. Ilegbusi
Olusegun J. Ilegbusi
University of Central Florida, Orlando, FL
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Behnaz Seyfi
University of Central Florida, Orlando, FL
Anand P. Santhanam
University of California, Los Angeles, Los Angeles, CA
Olusegun J. Ilegbusi
University of Central Florida, Orlando, FL
Paper No:
IMECE2012-86407, pp. 239-245; 7 pages
Published Online:
October 8, 2013
Citation
Seyfi, B, Santhanam, AP, & Ilegbusi, OJ. "Application of Fusion Algorithm to Human Lung Dynamics." Proceedings of the ASME 2012 International Mechanical Engineering Congress and Exposition. Volume 2: Biomedical and Biotechnology. Houston, Texas, USA. November 9–15, 2012. pp. 239-245. ASME. https://doi.org/10.1115/IMECE2012-86407
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