MRI guided focused ultrasound (FUS) has been shown to create thermal lesions where tissue stiffness changes significantly. To assess the correlation between tissue stiffness change and tissue ablation, a pilot animal based study was conducted to treat LNCaP tumors in vivo and Hep3B tumors immediately post mortem. MR elastography was used to analyze tissue stiffness before and after ablation. Treated tissue was excised immediately after each experiment and processed by routine histological analysis. Four prostate cancer tumors and four liver cancer tumors showed, on average, a threefold increase in stiffness due to FUS thermal treatment. Histology showed complete (100%) coagulation necrosis in these cases. These data suggest that MRE may be an effective means to assess tissue ablation.
- Bioengineering Division
Magnetic Resonance Elastography Assessment of Focused Ultrasound Surgery in Cancer Models: A Pilot Study
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Primak, SV, Le, Y, Glaser, KJ, Reynold, CA, Lai, J, Roberts, LR, Rossman, PJ, Felmlee, JP, & Ehman, RL. "Magnetic Resonance Elastography Assessment of Focused Ultrasound Surgery in Cancer Models: A Pilot Study." Proceedings of the ASME 2006 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering, Biomedical and Safety Systems. Chicago, Illinois, USA. November 5–10, 2006. pp. 41-45. ASME. https://doi.org/10.1115/IMECE2006-16010
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