Biological agent detection has captured the attention of many researchers over the last few years. The present research explores the possibility of directly measuring the diffusion coefficients of sub-micron particles as a means of pathogen detection. At a constant temperature, the diffusion coefficient is simply a function of the drag on the particle. If the particles are functionalized with antibodies against a specific analyte and introduced into a sample containing that analyte, binding of the analyte with the particles will increase the particles' hydrodynamic drag. This results in a decrease in diffusion, which is measured by a particle tracking algorithm. The reduction in diffusion is correlated with the amount of analyte present. Sensitivity to experimental conditions is also explored and it is shown that alternate methods like optical traps provide an even better technique for biological agent detection.
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ASME 2006 International Mechanical Engineering Congress and
Exposition
November 5–10, 2006
Chicago, Illinois, USA
Conference Sponsors:
- Fluids Engineering Division
ISBN:
0-7918-4770-5
PROCEEDINGS PAPER
Biological Agent Detection Using Optical Diffusometry Methods
Steve Wereley
Steve Wereley
Purdue University
Search for other works by this author on:
Aloke Kumar
Purdue University
Venu Gorti
Purdue University
Steve Wereley
Purdue University
Paper No:
IMECE2006-13267, pp. 743-750; 8 pages
Published Online:
December 14, 2007
Citation
Kumar, A, Gorti, V, & Wereley, S. "Biological Agent Detection Using Optical Diffusometry Methods." Proceedings of the ASME 2006 International Mechanical Engineering Congress and Exposition. Fluids Engineering. Chicago, Illinois, USA. November 5–10, 2006. pp. 743-750. ASME. https://doi.org/10.1115/IMECE2006-13267
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