Although the use of endovascular stents has significantly reduced the incidence of restenosis following balloon angioplasty, restenosis rates remain unacceptably high (20–35% of all angioplasty procedures ). Placement of a stent within an arterial segment locally injures vascular endothelium thereby stimulating thrombotic responses that contribute to the development of in-stent restenosis. Recent research suggests that the local fluid mechanical environment in the vicinity of a stent impacts the rate of vessel re-endothelialization following stent-induced injury . This is supported by in vitro data demonstrating that endothelial repair after injury is sensitive to fluid mechanical forces . Recent in vivo data suggest that in-stent restenosis preferentially develops in arterial regions exposed to low and/or oscillatory shear stress . Therefore, it is essential to establish the detailed flow environment in the vicinity of a stent and to investigate the impact of this environment on EC function.
Stent-Induced Arterial Flow Disturbance: Whole Vessel and Cellular Considerations
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Schachter, LG, Lieu, DK, & Barakat, AI. "Stent-Induced Arterial Flow Disturbance: Whole Vessel and Cellular Considerations." Proceedings of the ASME 2002 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering. New Orleans, Louisiana, USA. November 17–22, 2002. pp. 287-288. ASME. https://doi.org/10.1115/IMECE2002-32584
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