Although the use of endovascular stents has significantly reduced the incidence of restenosis following balloon angioplasty, restenosis rates remain unacceptably high (20–35% of all angioplasty procedures [1]). Placement of a stent within an arterial segment locally injures vascular endothelium thereby stimulating thrombotic responses that contribute to the development of in-stent restenosis. Recent research suggests that the local fluid mechanical environment in the vicinity of a stent impacts the rate of vessel re-endothelialization following stent-induced injury [2]. This is supported by in vitro data demonstrating that endothelial repair after injury is sensitive to fluid mechanical forces [3]. Recent in vivo data suggest that in-stent restenosis preferentially develops in arterial regions exposed to low and/or oscillatory shear stress [1]. Therefore, it is essential to establish the detailed flow environment in the vicinity of a stent and to investigate the impact of this environment on EC function.
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ASME 2002 International Mechanical Engineering Congress and Exposition
November 17–22, 2002
New Orleans, Louisiana, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-3650-9
PROCEEDINGS PAPER
Stent-Induced Arterial Flow Disturbance: Whole Vessel and Cellular Considerations
Levanto G. Schachter,
Levanto G. Schachter
University of California at Davis, Davis, CA
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Deborah K. Lieu,
Deborah K. Lieu
University of California at Davis, Davis, CA
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Abdul I. Barakat
Abdul I. Barakat
University of California at Davis, Davis, CA
Search for other works by this author on:
Levanto G. Schachter
University of California at Davis, Davis, CA
Deborah K. Lieu
University of California at Davis, Davis, CA
Abdul I. Barakat
University of California at Davis, Davis, CA
Paper No:
IMECE2002-32584, pp. 287-288; 2 pages
Published Online:
June 3, 2008
Citation
Schachter, LG, Lieu, DK, & Barakat, AI. "Stent-Induced Arterial Flow Disturbance: Whole Vessel and Cellular Considerations." Proceedings of the ASME 2002 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering. New Orleans, Louisiana, USA. November 17–22, 2002. pp. 287-288. ASME. https://doi.org/10.1115/IMECE2002-32584
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