A flow boiling heat transfer experimental investigation on the shell-side of a smooth tube and two enhanced tubes (C-EHT, P-EHT) was performed using R410A as working fluid. The outer surface of the C-EHT tube is covered with special fins having a salient height, and the inner surface has a thread structure with the same distribution density. The outer surface of the P-EHT tube has lots of tiny pits formed by high-strength sandblasting and smooth inner surface. The inlet and outlet vapor quality is 0.2 and 0.8 at a saturation temperature of 279K. The flow boiling experimental results show that the evaporation heat transfer coefficient of C-EHT tube is the largest among the tested tubes. However, for the P-EHT tube, its heat transfer coefficient is lower than that of smooth tube. C-EHT tube with special fins has higher heat transfer area, which can also intensify the interfacial turbulence with increasing fins. The reason why the flow boiling heat transfer coefficient of the P-EHT tube is lower than that of the smooth tube is that the diameter of the pit on P-EHT tube is too small to form the nucleation cites, which results in bubble retention under the condition of low mass flux and deteriorates the flow boiling heat transfer performance.