Under the pressure of climate change, renewable energy gradually replaces fossil fuels and plays nowadays a significant role in energy production. Among different types of energy sources, wind power covered 14% of the EU’s electricity demand in 2018. The Operations and Maintenance (O&M) costs of wind turbines may easily reach up to 20–25% of the total leverised cost per kWh produced over the lifetime of the turbine for a new unit. According to Wood Mackenzie Power & Renewables (WMPR) onshore wind farm operators are expected to spend nearly $15 billion on O&M services in 2019. Manufacturers and operators try to reduce O&M on one hand by developing new turbine designs and on the other hand by adopting condition monitoring approaches. One of the most critical and rather complex assembly of wind turbines is the gearbox. Gearboxes are designed to last till the end of asset’s lifetime, according to the IEC 61400-4 standards. On the other hand, a recent study over approximately 350 offshore wind turbines indicated that gearboxes might have to be replaced as early as 6.5 years. Therefore a plethora of sensor types and signal processing methodologies have been proposed in order to accurately detect and diagnose the presence of a fault. Among others, Envelope Analysis is one of the most important methodologies, where an envelope of the vibration signal is estimated, usually after filtering around a selected frequency band excited by impacts due to the fault. Sometimes the gearbox is equipped with many acceleration sensors and its kinematics is clearly known. In these cases Cyclostationary Analysis and the corresponding methodologies, i.e. the Cyclic Spectral Correlation and the Cyclic Spectral Coherence, have been proposed as powerful tools. On the other hand often the gearbox is equipped with a limited number of sensors and a simple global diagnostic indicator is demanded, being capable to detect globally various faults of different components. The scope of this paper is the application and comparison of a number of blind global diagnostic indicators which are based on Entropy (Permutation entropy, Approximate entropy, Samples entropy, Fuzzy entropy, Conditional entropy and Wiener entropy), on Negentropy (Infogram), on Sparsity (Sparse-L2/L1, Sparse-L1/L0, Sparse-Gini index) and on Statistics (Mean, Standard deviation, Kurtosis, etc.). The performance of the indicators is evaluated and compared on a wind turbine data set, consisted of vibration data captured by one accelerometer mounted on six 2.5 MW wind turbines, located in a wind park in northern Sweden, where two different bearing faults have been filed, for one wind turbine, during a period of 46 months. Among the different diagnostic indicators Permutation entropy, Approximate entropy, Samples entropy, Fuzzy entropy, Conditional entropy and Wiener entropy achieve the best results detecting blindly the two failure events.