There are few medical devices currently utilized that have not had, at the very least, a second iteration. Medical device companies continually strive to improve their product to make it the best on the market. Medical devices are often optimized by defining the size of the device, making it more efficient and/or improving the device to tissue interface. Using the capabilities of the Visible Heart® Laboratories various cardiac devices can be implanted in reanimated swine and human hearts for the assessment of the various aforementioned parameters. After the implantation of these devices and assessment in functional anatomies, specimens were perfusion-fixed and then a micro-CT scanner was utilized to take high-resolution scans of the resultant device and tissue interfaces. These scans are used to generate high-resolution (∼20 microns) 3D models of the numerous implanted devices, measurement analyses, device simulations, and the creation of virtual reality scenes. All can then be used for detailed visual analyses. These abilities to render high-resolution models will allow medical device designers to closely evaluate their designs, in order to optimize their next iterations.