We describe the formulation and manufacture of thermoplastic polyurethane (TPU)-based steroid-eluting components and the development of a versatile, material-agnostic analytical method for their rapid characterization. The impact of materials, formulation, and processing on controlled release behavior was characterized and compared to current industry standard components under physiologically relevant conditions. The combination of factors modulated drug release, offering new avenues for controlling the release of steroids from implantable medical devices.
Formulation and Characterization of Thermoplastic Polyurethane-Based Steroid Eluting Devices
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Doan, J, Phommahaxay, P, Olson, S, & Petersen, MA. "Formulation and Characterization of Thermoplastic Polyurethane-Based Steroid Eluting Devices." Proceedings of the 2019 Design of Medical Devices Conference. 2019 Design of Medical Devices Conference. Minneapolis, Minnesota, USA. April 15–18, 2019. V001T10A010. ASME. https://doi.org/10.1115/DMD2019-3254
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